INT135675

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.38
Pain Relevance 5.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a3)
Anatomy Link Frequency
astrocytes 2
spinal cord dorsal horn 2
Slc1a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 43 100.00 Very High Very High Very High
Antinociceptive 9 100.00 Very High Very High Very High
tolerance 9 100.00 Very High Very High Very High
Morphine 33 99.86 Very High Very High Very High
Spinal cord 12 98.76 Very High Very High Very High
Endep 16 98.58 Very High Very High Very High
opiate 10 98.28 Very High Very High Very High
Dorsal horn 6 98.28 Very High Very High Very High
intrathecal 1 88.04 High High
sodium channel 1 86.56 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 13 85.20 High High
Pain 3 81.24 Quite High
Injury 3 77.84 Quite High
INFLAMMATION 3 25.00 Low Low
Hypersensitivity 4 16.80 Low Low
Nociception 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that amitriptyline alone did not produce an antinociceptive effect, while morphine alone induced antinociceptive tolerance and down-regulation of spinal glutamate transporters (GLAST, GLT-1, and EAAC1) in the rat spinal cord dorsal horn.
Positive_regulation (induced) of Negative_regulation (down-regulation) of GLAST in spinal cord dorsal horn associated with glutamate, dorsal horn, tolerance, antinociceptive, endep, spinal cord and morphine
1) Confidence 0.45 Published 2006 Journal Pain Section Abstract Doc Link 16697108 Disease Relevance 0 Pain Relevance 1.71
In morphine-tolerant rats, acute treatment with PKA inhibitor H89 and PKC inhibitor Gö6805 attenuated morphine tolerance and the morphine-induced CSF glutamate and aspartate elevation, and induced trafficking of GLAST and GLT-1 from cytosol onto the cell surface.
Positive_regulation (induced) of Negative_regulation (trafficking) of GLAST associated with glutamate, tolerance and morphine
2) Confidence 0.42 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 2.02
The results from the above suggest that the decrease in GLT-1 and GLAST, which was induced by PNSL, mainly occurred in astrocytes on the injured side.


Positive_regulation (induced) of Negative_regulation (decrease) of GLAST in astrocytes
3) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.23 Pain Relevance 0.08
We show that non-selective glutamate transporter inhibition increases the rate of spontaneous excitatory post-synaptic currents (sEPSCs) in the opiate naïve, but not opiate tolerant slice.
Positive_regulation (increases) of Negative_regulation (inhibition) of glutamate transporter associated with glutamate and opiate
4) Confidence 0.32 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16949209 Disease Relevance 0.15 Pain Relevance 2.06

General Comments

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