INT135722

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.52
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ANGPTL5) extracellular space (ANGPTL5) extracellular region (ANGPTL5)
Anatomy Link Frequency
joints 2
hepatocytes 2
ANGPTL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 49 99.92 Very High Very High Very High
Inflammatory response 26 98.92 Very High Very High Very High
Angina 10 97.72 Very High Very High Very High
Arthritis 107 97.20 Very High Very High Very High
Inflammatory mediators 3 84.88 Quite High
cytokine 8 69.92 Quite High
rheumatoid arthritis 23 5.00 Very Low Very Low Very Low
antagonist 17 5.00 Very Low Very Low Very Low
withdrawal 9 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 81 99.92 Very High Very High Very High
Atherosclerosis 11 99.28 Very High Very High Very High
Alzheimer's Dementia 2 97.84 Very High Very High Very High
Stable Angina Pectoris 8 97.72 Very High Very High Very High
Disease 113 97.60 Very High Very High Very High
Arthritis 40 97.20 Very High Very High Very High
Myocardial Infarction 9 96.64 Very High Very High Very High
Alpha-1-antitrypsin Deficiency 5 91.60 High High
Coronary Artery Disease 17 87.36 High High
Renal Failure 1 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depending crucially on the extent to which it may or may not eventually be possible to apportion any clinical benefits between its fibrinogen-lowering and lipid-modifying effects, trials of bezafibrate may therefore offer opportunities for assessing the effects of lowering fibrinogen levels
Positive_regulation (lowering) of Gene_expression (levels) of fibrinogen
1) Confidence 0.39 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 0.76 Pain Relevance 0.04
Importance of fibrinogen adsorption in implant-mediated acute inflammatory response in humans
Positive_regulation (Importance) of Gene_expression (adsorption) of fibrinogen associated with inflammatory response
2) Confidence 0.14 Published 2007 Journal J Transl Med Section Body Doc Link PMC1929055 Disease Relevance 0.45 Pain Relevance 0.09
The aims of the present study were to investigate serum leptin concentrations in patients with ST-elevated myocardial infarction (STEMI) and with chronic stable angina pectoris (CSAP) and to evaluate the possible correlations of leptin to other atherosclerotic risk factors; including serum high sensitive C-reactive protein (Hs-CRP), serum homocysteine, and fibrinogen concentrations.
Positive_regulation (sensitive) of Gene_expression (concentrations) of fibrinogen associated with stable angina pectoris, angina, atherosclerosis and myocardial infarction
3) Confidence 0.07 Published 2006 Journal Angiology Section Abstract Doc Link 16703186 Disease Relevance 1.20 Pain Relevance 0.51
Increased fibrinogen and fibrin deposition within joints are prominent indicators of active SJIA flare [46] and arthritis [47].
Positive_regulation (Increased) of Gene_expression (deposition) of fibrinogen in joints associated with arthritis
4) Confidence 0.05 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.85 Pain Relevance 0.17
During acute inflammation IL-6 stimulates hepatocytes to produce acute-phase proteins such as CRP, haptoglobin, fibrinogen, ?
Positive_regulation (stimulates) of Gene_expression (produce) of fibrinogen in hepatocytes associated with inflammation
5) Confidence 0.01 Published 2010 Journal Core evidence Section Body Doc Link PMC2899792 Disease Relevance 1.26 Pain Relevance 0.24

General Comments

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