INT135729

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 6.86
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Zap70)
Anatomy Link Frequency
lymph node 1
blood 1
B cell 1
T cells 1
Zap70 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 100 97.00 Very High Very High Very High
rheumatoid arthritis 53 95.44 Very High Very High Very High
Etanercept 7 77.20 Quite High
Angina 1 66.52 Quite High
Pain 1 63.16 Quite High
headache 1 58.36 Quite High
Inflammation 8 38.72 Quite Low
chemokine 15 18.96 Low Low
cytokine 18 5.00 Very Low Very Low Very Low
corticosteroid 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 1 99.76 Very High Very High Very High
Infection 63 99.28 Very High Very High Very High
Chronic Lymphoid Leukemia 294 98.88 Very High Very High Very High
Arthritis 118 97.00 Very High Very High Very High
Toxicity 40 96.24 Very High Very High Very High
Cytomegalovirus Infection 24 96.16 Very High Very High Very High
Rheumatoid Arthritis 59 95.44 Very High Very High Very High
Residual Neoplasm 18 94.32 High High
Disease 107 92.64 High High
Death 9 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis resulted in a significant expression (p<0.05) of the 70-kDa heat shock protein in 2,6-DNT-treated cells compared to the control cells and at the 200 microg/mL dose for 2,4-DNT.
Gene_expression (expression) of 70-kDa associated with shock
1) Confidence 0.75 Published 2005 Journal Int J Environ Res Public Health Section Abstract Doc Link 16705839 Disease Relevance 1.34 Pain Relevance 0.19
Second, a spontaneous point mutation in the gene encoding an Src homology 2 (SH2) domain of ZAP-70, a key signal transduction molecule in T cells, causes chronic autoimmune arthritis in mice that resembles human RA in many respects [25].
Gene_expression (domain) of ZAP-70 in T cells associated with rheumatoid arthritis and arthritis
2) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.00 Pain Relevance 0.42
There was no significant correlation between response rate and quality of response and biological markers (IgVH mutation status, FISH status, or ZAP70 or CD38 expression).
Gene_expression (expression) of ZAP70
3) Confidence 0.21 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004569 Disease Relevance 0.70 Pain Relevance 0
70 years, or those with adverse cytogenetics, unmutated IGHV genes or high expression of ZAP-70 or CD38 was observed.59
Gene_expression (expression) of ZAP-70
4) Confidence 0.19 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004569 Disease Relevance 1.03 Pain Relevance 0.07
70 years, or those with adverse cytogenetics, unmutated IGHV genes or high expression of ZAP-70 or CD38 was observed.59
Gene_expression (observed.59) of ZAP-70
5) Confidence 0.19 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004569 Disease Relevance 1.04 Pain Relevance 0.07
Wang et al. collected and analyzed 33 lymph nodes and 37 blood CLL samples and analyzed IgH mutation status, ZAP-70 expression status and expression of 15 miRNAs.
Spec (analyzed) Gene_expression (expression) of ZAP-70 in blood
6) Confidence 0.12 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.55 Pain Relevance 0
Sixty-three percent of the lymph node cases contained mutated IgH genes and 49% of the lymph node cases were ZAP-70-positive, and a significant correlation was observed between ZAP-70 expression and IgH mutation status.
Gene_expression (expression) of ZAP-70 in lymph node
7) Confidence 0.12 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.35 Pain Relevance 0
Several miRNAs have been reported to be associated with IgH mutation and ZAP-70 expression status in blood samples of B cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL).
Gene_expression (expression) of ZAP-70 in B cell associated with chronic lymphoid leukemia
8) Confidence 0.11 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.78 Pain Relevance 0

General Comments

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