INT135768

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.17
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Fbrs (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 2 96.20 Very High Very High Very High
Acupuncture 7 93.04 High High
anesthesia 7 90.96 High High
depression 1 25.00 Low Low
Inflammation 28 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 60 100.00 Very High Very High Very High
Apoptosis 204 98.64 Very High Very High Very High
Anxiety Disorder 4 94.24 High High
Clostridium Infection 4 41.60 Quite Low
Respiratory Failure 1 25.00 Low Low
Atherosclerosis 140 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Atherosclerotic Plaque 12 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 12 5.00 Very Low Very Low Very Low
Fibrosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a prospective double-blind study, we enrolled 48 patients scheduled to undergo diagnostic FBS.
Positive_regulation (undergo) of FBS
1) Confidence 0.40 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 16710890 Disease Relevance 0.25 Pain Relevance 0.50
VSMCs were incubated under two different conditions: FBS or TGF-?
Positive_regulation (incubated) of FBS
2) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.60 Pain Relevance 0
We have observed in VSMCs that preincubation with L-mevalonate, the direct HMG-CoA reductase metabolite, or GGPP, completely abolished simvastatin-induced cell death in both 10% FBS and in TGF-?
Positive_regulation (induced) of FBS associated with death
3) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.76 Pain Relevance 0
Treatment with two different farnesyl transferase inhibitors (FTI-277 or FTS) for 48h did not induce VSMC death in 10%FBS (Figure 3c).
Neg (not) Positive_regulation (induce) of FBS associated with death
4) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.78 Pain Relevance 0
To evaluate the involvement of the Smad pathway in statin-induced cell death in 10% FBS, cells were transiently transfected with a Smad7 overexpressing vector that inhibits TGF-?
Positive_regulation (induced) of FBS associated with death
5) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.78 Pain Relevance 0

General Comments

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