INT135772

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.52
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1) enzyme binding (HMOX1)
transmembrane transport (HMOX1) signal transducer activity (HMOX1) cytosol (HMOX1)
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 4 96.96 Very High Very High Very High
antagonist 1 94.88 High High
Inflammation 8 89.76 High High
cINOD 3 79.20 Quite High
agonist 1 77.12 Quite High
cytokine 1 68.56 Quite High
cOX1 2 25.00 Low Low
COX2 1 25.00 Low Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 15 99.02 Very High Very High Very High
INFLAMMATION 8 89.76 High High
Toxicity 20 85.68 High High
Injury 1 79.28 Quite High
Cancer 10 75.00 Quite High
Necrosis 4 75.00 Quite High
Atherosclerosis 2 59.16 Quite High
Disorder Of Lipid Metabolism 4 5.00 Very Low Very Low Very Low
Acid Base Imbalance 3 5.00 Very Low Very Low Very Low
Renal Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of cyclooxygenase isoforms 1 and 2 remained unaffected, and COX-inhibitors did not antagonize HO-1 induction by PPIs.
Neg (not) Regulation (antagonize) of Neg (not) Positive_regulation (induction) of HO-1
1) Confidence 0.39 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16712795 Disease Relevance 0.17 Pain Relevance 0.08
The finding that LSS-dependent reduction of TNF-alpha generation and HO-1 induction were abrogated by the selective inhibitor of COX-2 NS-398, the nonselective COX inhibitor aspirin, or the specific prostacyclin receptor (IP) antagonist RO3244794 illuminates the central role played by LSS-induced COX-2-dependent prostacyclin in restraining endothelial inflammation.
Regulation (abrogated) of Positive_regulation (induction) of HO-1 associated with stress, aspirin, inflammation and antagonist
2) Confidence 0.39 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19122175 Disease Relevance 1.07 Pain Relevance 0.21
leads to an induction of heme oxygenase 1 (HO-1) in a dose-dependent manner in
Regulation (dependent) of Positive_regulation (induction) of HO-1
3) Confidence 0.07 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809332 Disease Relevance 0.29 Pain Relevance 0

General Comments

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