INT135779

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.79
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pax6) nucleolus (Pax6) nucleus (Pax6)
intracellular (Pax6) DNA binding (Pax6) cytoplasm (Pax6)
Anatomy Link Frequency
smooth muscle 2
lens 2
lens fiber 2
Pax6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 11 96.44 Very High Very High Very High
diclofenac 8 96.12 Very High Very High Very High
cINOD 1 72.64 Quite High
Inflammation 3 67.92 Quite High
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disseminated Intravascular Coagulation 6 96.12 Very High Very High Very High
Cataract 9 78.36 Quite High
Capsule Opacification 13 75.00 Quite High
INFLAMMATION 4 72.40 Quite High
Overdose 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Hyphema 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As we know, the loss of Pax6 expression in lens fiber cells is essential for normal fiber cell differentiation and crystallin gene expression [5].
Negative_regulation (loss) of Gene_expression (expression) of Pax6 in lens fiber
1) Confidence 0.57 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
At 3 months after lens extraction, the expression of Pax6 decreased noticeably.
Negative_regulation (decreased) of Gene_expression (expression) of Pax6 in lens
2) Confidence 0.57 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
With or without drug addition, most cells became aberrant, as indicated by loss of Pax6 expression and the presence of PCO markers alpha-smooth muscle actin and type I collagen; however, DEX and DIC both strongly enhanced type I collagen accumulation.
Negative_regulation (loss) of Gene_expression (expression) of Pax6 in smooth muscle associated with diclofenac and dexamethasone
3) Confidence 0.49 Published 2006 Journal Exp. Eye Res. Section Abstract Doc Link 16713596 Disease Relevance 0.79 Pain Relevance 0.80

General Comments

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