INT135780

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 22
Disease Relevance 3.17
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pax6) nucleolus (Pax6) nucleus (Pax6)
intracellular (Pax6) DNA binding (Pax6) cytoplasm (Pax6)
Anatomy Link Frequency
retinas 3
lens 3
amacrine cells 3
lens fiber 3
ganglion cells 2
Pax6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 20 96.44 Very High Very High Very High
diclofenac 8 96.12 Very High Very High Very High
Central nervous system 4 95.08 Very High Very High Very High
Enkephalin 27 74.92 Quite High
Dopamine 18 74.04 Quite High
Neurotransmitter 36 73.36 Quite High
cINOD 1 72.32 Quite High
gABA 36 68.56 Quite High
Inflammation 13 67.92 Quite High
withdrawal 2 62.24 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 221 100.00 Very High Very High Very High
Disseminated Intravascular Coagulation 6 96.12 Very High Very High Very High
Diabetic Retinopathy 14 80.60 Quite High
Cataract 36 78.04 Quite High
Diabetes Mellitus 93 77.80 Quite High
Capsule Opacification 67 75.00 Quite High
INFLAMMATION 14 72.08 Quite High
Hyperglycemia 5 53.44 Quite High
Congenital Anomalies 7 52.20 Quite High
Hypertension 31 50.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pax6 protein was detected with immunofluorescence and found primarily in the epithelium.
Gene_expression (detected) of Pax6 protein in epithelium
1) Confidence 0.76 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
As we know, the loss of Pax6 expression in lens fiber cells is essential for normal fiber cell differentiation and crystallin gene expression [5].
Gene_expression (expression) of Pax6 in lens fiber
2) Confidence 0.76 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Pax6 protein, which was detected in the cytoplasm and nucleus, was predominately expressed in the LECs and to a lesser extent in the lens fiber cells (Figure 5).
Gene_expression (detected) of Pax6 protein in lens fiber
3) Confidence 0.76 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
At 3 months after lens extraction, the expression of Pax6 decreased noticeably.
Gene_expression (expression) of Pax6 in lens
4) Confidence 0.76 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Pax6 protein was also expressed in the cornea, iris, and retina (data not shown).
Gene_expression (expressed) of Pax6 protein in retina
5) Confidence 0.76 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
With or without drug addition, most cells became aberrant, as indicated by loss of Pax6 expression and the presence of PCO markers alpha-smooth muscle actin and type I collagen; however, DEX and DIC both strongly enhanced type I collagen accumulation.
Gene_expression (expression) of Pax6 in smooth muscle associated with diclofenac and dexamethasone
6) Confidence 0.65 Published 2006 Journal Exp. Eye Res. Section Abstract Doc Link 16713596 Disease Relevance 0.79 Pain Relevance 0.80
These cells can be identified by their ability to proliferate based on the incorporation of bromodeoxyuridine (BrdU), and by the expression of progenitor markers such as nestin, membrane receptor tyrosine kinase, also designated vascular endothelial growth factor receptor-2 (Flk-1), and paired box gene 6 (Pax6) [24-27]. p27Kip1 has recently been implicated in the molecular mechanism that controls the decision of multipotent central nervous system progenitors to withdraw from the cell cycle and to maintain the differentiated state of the postmitotic cell [28].
Gene_expression (expression) of paired box gene 6 in central nervous system associated with central nervous system
7) Confidence 0.60 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.57 Pain Relevance 0.08
Real-time PCR and/or immunofluorescence were performed to detect the expression of the lens transcription factors paired box 6 (Pax6), prospero homeobox 1 (Prox1), and forkhead box E3 (Foxe3) and ?
Gene_expression (expression) of Pax6 in lens
8) Confidence 0.59 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Real-time PCR and/or immunofluorescence were performed to detect the expression of the lens transcription factors paired box 6 (Pax6), prospero homeobox 1 (Prox1), and forkhead box E3 (Foxe3) and ?
Gene_expression (expression) of paired box 6 in lens
9) Confidence 0.59 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Pax6 protein, which was detected in the cytoplasm and nucleus, was predominately expressed in the LECs and to a lesser extent in the lens fiber cells (Figure 5).
Gene_expression (expressed) of Pax6 protein in lens fiber
10) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
The relative expression quantities of Pax6 and Prox1 immediately after ECLE decreased noticeably as visualized by real-time PCR, shown in Figure 8.
Gene_expression (expression) of Pax6
11) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Pax6 protein was also expressed in the cornea, iris, and retina (data not shown).
Gene_expression (expressed) of Pax6 protein in cornea
12) Confidence 0.26 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Pax6 protein was also expressed in the cornea, iris, and retina (data not shown).
Gene_expression (expressed) of Pax6 protein in iris
13) Confidence 0.26 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2834568 Disease Relevance 0 Pain Relevance 0
Pax6 is expressed at low levels in progenitors and becomes expressed at high levels in amacrine and ganglion cells as they differentiate [30,31].
Gene_expression (expressed) of Pax6 in ganglion cells associated with ganglion cysts
14) Confidence 0.15 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.26 Pain Relevance 0
In E7 and E11 retinas, type-I and type-II cholinergic amacrine cells expressed relatively low levels of Pax6; Pax6-immunolabeling was more intense in the nuclei of non-cholinergic neurons in the GCL and INL compared to the labeling intensity of the nuclei of the ChAT-immunoreactive cells (Figs. 2a–f).
Gene_expression (expressed) of Pax6 in retinas
15) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.25 Pain Relevance 0
As the cholinergic amacrine cells differentiate they express proteins common to other types of amacrine cells such as Pax6, CRABP and p27kip1.
Gene_expression (express) of Pax6 in amacrine cells
16) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0 Pain Relevance 0
In E7 and E11 retinas, type-I and type-II cholinergic amacrine cells expressed relatively low levels of Pax6; Pax6-immunolabeling was more intense in the nuclei of non-cholinergic neurons in the GCL and INL compared to the labeling intensity of the nuclei of the ChAT-immunoreactive cells (Figs. 2a–f).
Gene_expression (expressed) of Pax6 in retinas
17) Confidence 0.13 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.25 Pain Relevance 0
Pax6 is expressed at low levels in progenitors and becomes expressed at high levels in amacrine and ganglion cells as they differentiate [30,31].
Gene_expression (expressed) of Pax6 in ganglion cells associated with ganglion cysts
18) Confidence 0.11 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.27 Pain Relevance 0
Accordingly, this microenvironment may promote the expression of genes common to both ganglion and type-II cells (including Pax6, Islet1 and neurofilament).
Gene_expression (expression) of Pax6 in ganglion associated with ganglion cysts
19) Confidence 0.11 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.54 Pain Relevance 0.15
We found that as ChAT-immunoreactive cells differentiate they expressed the homeodomain transcription factors Pax6 and Islet1, and the cell-cycle inhibitor p27kip1.
Gene_expression (expressed) of Pax6
20) Confidence 0.11 Published 2008 Journal BMC Dev Biol Section Abstract Doc Link PMC2267169 Disease Relevance 0.09 Pain Relevance 0

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