INT135803

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.35
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
brain 2
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 122 97.68 Very High Very High Very High
Spinal cord 81 96.72 Very High Very High Very High
Inflammation 60 94.76 High High
narcan 1 94.48 High High
antagonist 2 93.76 High High
Opioid 2 93.28 High High
agonist 20 82.76 Quite High
Inflammatory response 9 64.24 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 28 99.16 Very High Very High Very High
Spinal Cord Injury 122 98.44 Very High Very High Very High
Apoptosis 134 97.56 Very High Very High Very High
Injury 35 95.28 Very High Very High Very High
INFLAMMATION 65 94.76 High High
Leishmaniasis 50 90.48 High High
Cancer 77 85.00 Quite High
Diffuse Cutaneous Leishmaniasis 74 83.36 Quite High
Adult Respiratory Distress Syndrome 3 78.32 Quite High
Liver Cancer 12 72.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of olprinone on FasL expression and on S100?
Regulation (Effects) of Gene_expression (expression) of FasL
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 1.31 Pain Relevance 0.41
Furthermore, cell death induced by reactive oxygen species (ROS) depends on FasL expression mediated by redox sensitive activation of NF-?
Regulation (depends) of Gene_expression (expression) of FasL associated with death
2) Confidence 0.34 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.88 Pain Relevance 0.20
We did not observe any changes in either Fas or FasL expression in U0126-treated HepG2 and Hep3B cells.
Neg (not) Regulation (changes) of Gene_expression (expression) of FasL
3) Confidence 0.30 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.00 Pain Relevance 0
The purpose of the present study was to analyse the effects of naltrexone on the expression levels of proteins regulating the extrinsic (FasL and Fas) and the mitochondrial (Bcl-2, Bcl-xL, Bad and Bax) apoptotic pathways, as well as the active fragment of the executioner caspase-3 in the mouse brain.
Spec (analyse) Regulation (effects) of Spec (analyse) Gene_expression (expression) of FasL in brain associated with apoptosis
4) Confidence 0.26 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16716514 Disease Relevance 0.26 Pain Relevance 0.30
, IL-10) and changes in serum Fas Ligand (FasL) levels in patients undergoing neurosurgical procedures.


Regulation (changes) of Gene_expression (levels) of Fas Ligand
5) Confidence 0.25 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0 Pain Relevance 0.17
, IL-10) and changes in serum Fas Ligand (FasL) levels in patients undergoing neurosurgical procedures.


Regulation (changes) of Gene_expression (levels) of FasL
6) Confidence 0.25 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0 Pain Relevance 0.17
Whereas FasL expression remained unchanged, granzyme B expression decreased significantly (p<0.01) (Figure 2B) after the cytotoxic challenge, which suggests that cytotoxicity is mediated by cytotoxic granules.


Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of FasL
7) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.90 Pain Relevance 0

General Comments

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