INT135804

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.24
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
brains 2
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 1 87.88 High High
Demyelination 1 86.24 High High
narcan 1 81.60 Quite High
antagonist 3 80.88 Quite High
Opioid 2 80.40 Quite High
anesthesia 4 29.52 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
intrathecal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 10 99.88 Very High Very High Very High
Neurodegenerative Disease 8 96.88 Very High Very High Very High
Apoptosis 13 93.48 High High
Demyelinating Disease 2 87.88 High High
Brain Injury 38 82.60 Quite High
Targeted Disruption 10 62.32 Quite High
Death 14 50.00 Quite Low
Disease 4 5.00 Very Low Very Low Very Low
Closed Head Injuries 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting showed that a single injection of naltrexone (1 mg/kg) induced a down-regulation of the pro-apototic proteins Fas, FasL, Bad and Bax.
Positive_regulation (induced) of Negative_regulation (down-regulation) of Fas
1) Confidence 0.56 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16716514 Disease Relevance 0.24 Pain Relevance 0.27
Upregulation of Bcl-2 and downregulation of Fas in injured fB-/- brains
Positive_regulation (Upregulation) of Negative_regulation (downregulation) of Fas in brains
2) Confidence 0.31 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 1.00 Pain Relevance 0.09

General Comments

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