INT135806

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.21
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bcl2l1) cytosol (Bcl2l1) mitochondrion (Bcl2l1)
growth (Bcl2l1) cytoskeleton (Bcl2l1) intracellular (Bcl2l1)
Anatomy Link Frequency
brain 3
IEC-6 1
superior 1
Bcl2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 2 97.38 Very High Very High Very High
methadone 2 97.08 Very High Very High Very High
narcan 1 92.12 High High
antagonist 2 91.40 High High
Opioid 3 90.92 High High
chemokine 22 89.84 High High
cytokine 13 84.40 Quite High
metalloproteinase 12 76.56 Quite High
Inflammation 27 76.16 Quite High
Hippocampus 1 65.92 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 220 99.72 Very High Very High Very High
Breast Cancer 27 98.80 Very High Very High Very High
Reprotox - General 1 1 98.64 Very High Very High Very High
Cognitive Disorder 5 98.24 Very High Very High Very High
Cancer 220 97.84 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 3 97.04 Very High Very High Very High
Hepatocellular Cancer 84 96.00 Very High Very High Very High
Stress 22 94.72 High High
Colon Cancer 73 93.80 High High
Death 39 88.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: This study analyzes the effects of prolonged administration of methadone and withdrawal on sensorimotor and cognitive performance in mice and explores the associated changes in brain expression of proteins regulating the extrinsic (FasL, Fas, and caspase-8) and the mitochondrial (Bcl-2, Bcl-x(L), Bad, and Bax) apoptotic pathways.
Regulation (regulating) of Bcl-x in brain associated with cognitive disorder, methadone, apoptosis and withdrawal
1) Confidence 0.44 Published 2007 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 17384938 Disease Relevance 0.35 Pain Relevance 0.26
Here, we have analyzed the effects of prolonged heroin administration on sensorimotor and cognitive performance in mice, as well as the associated changes in brain expression of proteins regulating the extrinsic (FasL and Fas) and the mitochondrial (Bcl-2, Bcl-X(L), Bad and Bax) apoptotic pathways.
Regulation (regulating) of Bcl-X in brain associated with cognitive disorder and apoptosis
2) Confidence 0.44 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18201731 Disease Relevance 0.72 Pain Relevance 0.12
The purpose of the present study was to analyse the effects of naltrexone on the expression levels of proteins regulating the extrinsic (FasL and Fas) and the mitochondrial (Bcl-2, Bcl-xL, Bad and Bax) apoptotic pathways, as well as the active fragment of the executioner caspase-3 in the mouse brain.
Regulation (regulating) of Bcl-xL in brain associated with apoptosis
3) Confidence 0.33 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16716514 Disease Relevance 0.26 Pain Relevance 0.30
Although AS therapy targeting Bcl-2 and Bcl-xL enhances chemosensitivity in breast cancer cells, the effect of blocking Bcl-2 seems superior to that of Bcl-xL.
Regulation (targeting) of Bcl-xL in superior associated with breast cancer
4) Confidence 0.26 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 1.14 Pain Relevance 0
A large number of antiapoptotic factors, such as cIAPs, c-FLIP, and BclX, are controlled by NF-?
Regulation (controlled) of BclX
5) Confidence 0.22 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.95 Pain Relevance 0.22
Although it is well documented that apoptosis is also regulated by the Bcl-2 family of proteins [55], we do not detect any significant changes in the levels of Bax, Bad, Bcl-2 and Bcl-xL followed by U0126 treatment (data not shown).
Neg (not) Regulation (changes) of Bcl-xL associated with apoptosis
6) Confidence 0.16 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.68 Pain Relevance 0
Bcl-xL is a member of the Bcl-2 family that acts on the mitochondrial membrane to prevent release of caspase activators such as cytochrome-C [27].
Regulation (acts) of Bcl-xL
7) Confidence 0.13 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.12 Pain Relevance 0
Various cellular mediators regulate nSMase activity including anionic phospholipids, protein kinases phospholipase A2, caveolin, Bcl-2 and Bcl-xL and proteases [5], [7], [8].
Regulation (regulate) of Bcl-xL
8) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.62 Pain Relevance 0.11
Constitutive activation of MEK1 or MEK2 resulted in the up-regulation of the pro-survival proteins Mcl-1, Bcl-2 and, to a lesser extent, Bcl-xL in IEC-6 cells (Fig. 5B).
Regulation (regulation) of Bcl-xL in IEC-6
9) Confidence 0.07 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.88 Pain Relevance 0
Bcl-XL and Bad protein levels were unchanged between adherent and non-adherent CXCL12 and control cells.
Neg (unchanged) Regulation (unchanged) of Bcl-XL
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.49 Pain Relevance 0.04

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