INT135818

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 4
Cat2 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 4 94.88 High High
lidocaine 10 94.40 High High
Clonidine 4 50.00 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Clonidine enhances CAT-2 transcription in endotoxin-activated murine macrophages.


Positive_regulation (enhances) of Transcription (transcription) of CAT-2 in macrophages
1) Confidence 0.64 Published 2008 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Body Doc Link 18809522 Disease Relevance 0 Pain Relevance 0
The data indicated that clonidine significantly enhanced LPS-induced CAT-2 transcription.
Positive_regulation (enhanced) of Transcription (transcription) of CAT-2
2) Confidence 0.64 Published 2008 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Body Doc Link 18809522 Disease Relevance 0 Pain Relevance 0
Our data demonstrated that LPS significantly upregulated transcription of iNOS and CAT-2 but not GTPCH in stimulated macrophages.
Neg (not) Positive_regulation (upregulated) of Transcription (transcription) of CAT-2 in macrophages
3) Confidence 0.40 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717319 Disease Relevance 0 Pain Relevance 1.11

General Comments

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