INT135827

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gch1) nucleus (Gch1) protein complex assembly (Gch1)
protein complex (Gch1) cytoplasm (Gch1)
Anatomy Link Frequency
macrophages 4
Gch1 (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 20 99.70 Very High Very High Very High
tetrodotoxin 8 96.32 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore concluded that lidocaine significantly inhibits iNOS and CAT-2 and, in turn, enhances GTPCH transcription in LPS-stimulated macrophages via a mechanism that possibly involves the voltage-sensitive Na+ channel.
Positive_regulation (enhances) of Transcription (transcription) of GTPCH in macrophages associated with lidocaine
1) Confidence 0.58 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717319 Disease Relevance 0 Pain Relevance 1.04
Conversely, lidocaine significantly increased GTPCH transcription in LPS-stimulated macrophages.
Positive_regulation (increased) of Transcription (transcription) of GTPCH in macrophages associated with lidocaine
2) Confidence 0.45 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717319 Disease Relevance 0 Pain Relevance 1.16

General Comments

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