INT135836

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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.62
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod1) aging (Sod1) peroxisome (Sod1)
intracellular (Sod1) protein complex (Sod1) cytoplasm (Sod1)
Anatomy Link Frequency
plasma 1
Sod1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 3 97.88 Very High Very High Very High
projection neuron 2 95.92 Very High Very High Very High
GABAergic 1 95.16 Very High Very High Very High
gABA 2 92.28 High High
Cannabinoid receptor 1 90.68 High High
agonist 3 86.12 High High
anesthesia 3 81.08 Quite High
Cannabinoid 3 77.80 Quite High
adenocard 3 75.00 Quite High
Substantia nigra 1 67.84 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 50 98.16 Very High Very High Very High
Urological Neuroanatomy 17 94.48 High High
Stress 28 93.00 High High
Gestational Diabetes 9 91.60 High High
Injury 61 90.28 High High
Weight Gain 1 87.52 High High
Body Weight 40 77.56 Quite High
Hypertension 2 75.00 Quite High
Frailty 1 75.00 Quite High
Apoptosis 10 71.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found reductions in mRNA levels for superoxide dismutase-1 (SOD-1) and -2 (SOD-2), which indicated that 3NP reduced the endogenous antioxidant defences.
Negative_regulation (reductions) of SOD-1
1) Confidence 0.25 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17672854 Disease Relevance 0.07 Pain Relevance 0.71
The effect on AOE gene expression was strikingly similar in CuZnSOD, MnSOD, and Gpx-1, which were all decreased.
Negative_regulation (decreased) of CuZnSOD
2) Confidence 0.20 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.61 Pain Relevance 0
Cu,Zn-SOD, catalase, and Se-GSHpx are inactivated by hypochlorous acid in vitro [39].
Negative_regulation (inactivated) of Cu,Zn-SOD
3) Confidence 0.17 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 0.70 Pain Relevance 0
To measure Mn-SOD activity, Cu,Zn-SOD was inhibited with diethyldithiocarbamic acid (DDC) [17].
Negative_regulation (inhibited) of Cu,Zn-SOD
4) Confidence 0.11 Published 2004 Journal BMC Clin Pharmacol Section Body Doc Link PMC419708 Disease Relevance 0 Pain Relevance 0
Ethanol significantly decreased the plasma NO levels, reduced to oxidized glutathione ratio (GSH/GSSG) and antioxidant enzymes-superoxide dismutase (CuZn-SOD, and Mn-SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities while plasma NADPH oxidase activity and malondialdehyde (MDA) levels were significantly elevated compared to control.
Negative_regulation (decreased) of CuZn-SOD in plasma
5) Confidence 0.05 Published 2006 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16718371 Disease Relevance 0.24 Pain Relevance 0.11

General Comments

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