INT135852

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.21
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CFHR4)
Anatomy Link Frequency
bone marrow 1
CFHR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 8 99.96 Very High Very High Very High
Enkephalin 14 99.20 Very High Very High Very High
Pain 6 96.24 Very High Very High Very High
opioid receptor 2 86.88 High High
analgesia 2 85.20 High High
Neurotransmitter 2 83.56 Quite High
Cancer pain 2 57.96 Quite High
Antinociceptive 2 56.12 Quite High
Endogenous opioid 2 52.72 Quite High
Analgesic 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 4 96.24 Very High Very High Very High
Cancer Pain 2 57.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Through targeted gene manipulation such as hPPE gene transfection, this may offer a virtually unlimited safe cell supply for the treatment of opioid-sensitive pain in humans.
Gene_expression (transfection) of hPPE gene associated with pain and opioid
1) Confidence 0.00 Published 2006 Journal Cell Transplant Section Abstract Doc Link 16719057 Disease Relevance 0.10 Pain Relevance 1.00
Our in vitro data demonstrated that genetically engineered hMeSCs with transfected hPPE gene can constitutively produce opioid peptide Met-enkephalin at an augmented high level. hMeSCs are relatively easy to isolate from a patient's bone marrow aspirates and expand in culture by repeated passages.
Gene_expression (produce) of hPPE gene in bone marrow associated with enkephalin and opioid
2) Confidence 0.00 Published 2006 Journal Cell Transplant Section Abstract Doc Link 16719057 Disease Relevance 0.11 Pain Relevance 1.27

General Comments

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