INT135864

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.76
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Chrne) plasma membrane (Chrne)
Anatomy Link Frequency
germline 1
Chrne (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 16 100.00 Very High Very High Very High
antagonist 17 99.96 Very High Very High Very High
Kappa opioid receptor 4 94.92 High High
opioid receptor 12 91.12 High High
medulla 2 75.20 Quite High
antinociception 8 61.92 Quite High
tail-flick 2 60.40 Quite High
mu opioid receptor 2 44.08 Quite Low
Pain 13 5.00 Very Low Very Low Very Low
Neurobehavioral 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 15 100.00 Very High Very High Very High
Targeted Disruption 24 82.40 Quite High
Syndrome 176 66.72 Quite High
Cancer 85 66.28 Quite High
Infection 3 55.88 Quite High
Skin Cancer 2 52.48 Quite High
Hyperphagia 48 50.00 Quite Low
Obesity 48 5.00 Very Low Very Low Very Low
Anxiety Disorder 30 5.00 Very Low Very Low Very Low
Body Weight 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deletion (1-loxP) ES cells were generated by transfecting doubly targeted (2-loxP) ES cell clone C3 with a Cre recombinase expression vector pBS185 (Invitrogen) to induce recombination between the loxP sites that removed ?
Gene_expression (expression) of a Cre
1) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0 Pain Relevance 0
150 kb deletion by transfecting doubly-targeted ES cells with a Cre recombinase expressing vector.
Gene_expression (expressing) of a Cre
2) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.22 Pain Relevance 0
GFP-positive cells were then isolated by FACS and transfected with a Cre expression-plasmid (pTURBO-Cre).
Gene_expression (expression) of a Cre
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.31 Pain Relevance 0
To generate null alleles we crossed the DPP6fl/fl mice to a Cre deleter strain expressing Cre recombinase in the germline (see Figure 1).
Gene_expression (expressing) of a Cre in germline associated with sprains and strains
4) Confidence 0.58 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0.24 Pain Relevance 0
Recently, we designed and synthesized the selective epsilon receptor agonist, 17-(cyclopropylmethyl)-4,5alpha-epoxy-3,6beta-dihydroxy-6,14-endoethenomorphinan-7alpha-[N-methyl-N-phenethyl]carboxamide (TAN-821), and the selective epsilon receptor antagonist, 17-(cyclopropylmethyl)-4,5alpha-epoxy-6beta,21-epoxymethano-3-hydroxy-6,14-endoe-thenomorphinan-7alpha-(N-phenethyl)carboxamide (TAN-1014).
Gene_expression (synthesized) of epsilon receptor associated with antagonist and agonist
5) Confidence 0.14 Published 2006 Journal Curr. Med. Chem. Section Abstract Doc Link 16719773 Disease Relevance 0 Pain Relevance 0.82
Recently, we designed and synthesized the selective epsilon receptor agonist, 17-(cyclopropylmethyl)-4,5alpha-epoxy-3,6beta-dihydroxy-6,14-endoethenomorphinan-7alpha-[N-methyl-N-phenethyl]carboxamide (TAN-821), and the selective epsilon receptor antagonist, 17-(cyclopropylmethyl)-4,5alpha-epoxy-6beta,21-epoxymethano-3-hydroxy-6,14-endoe-thenomorphinan-7alpha-(N-phenethyl)carboxamide (TAN-1014).
Gene_expression (synthesized) of epsilon receptor associated with antagonist and agonist
6) Confidence 0.14 Published 2006 Journal Curr. Med. Chem. Section Abstract Doc Link 16719773 Disease Relevance 0 Pain Relevance 0.66

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