INT135880

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 7.52
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf23) extracellular space (Fgf23) extracellular region (Fgf23)
Anatomy Link Frequency
fibroblast 2
kidney 2
Fgf23 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 8 87.44 High High
Somatostatin 2 74.96 Quite High
agonist 4 66.96 Quite High
Bile 64 55.44 Quite High
cytokine 4 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
sodium channel 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Failure 4 99.28 Very High Very High Very High
Rickets 220 99.08 Very High Very High Very High
Hypophosphatemia 45 97.04 Very High Very High Very High
Hypercalcemia 6 96.56 Very High Very High Very High
Disease 44 95.68 Very High Very High Very High
Syndrome 12 95.24 Very High Very High Very High
Cancer 44 95.04 Very High Very High Very High
Metabolic Disorder 32 94.36 High High
Growth Problems 8 89.76 High High
Pain 8 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum levels of FGF23 are found to be elevated in most but not all patients with proven TIO.
Positive_regulation (elevated) of Gene_expression (levels) of FGF23 associated with rickets
1) Confidence 0.46 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.98 Pain Relevance 0.04
The renal phosphate wasting is not intrinsic to the kidney but likely due to an increase in serum levels of fibroblast growth factor-23 (FGF-23), and perhaps other phosphate-wasting peptides previously known as phosphatonins.
Positive_regulation (increase) of Gene_expression (levels) of FGF-23 in fibroblast
2) Confidence 0.46 Published 2006 Journal Pediatr. Nephrol. Section Abstract Doc Link 16721588 Disease Relevance 1.08 Pain Relevance 0.17
Serum Fgf23 levels are also greatly increased in patients with renal failure, partly owing to decreased renal clearance.
Positive_regulation (increased) of Gene_expression (levels) of Fgf23 associated with renal failure
3) Confidence 0.45 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.93 Pain Relevance 0
Fgf23 mutations in ADHR result in impaired proteolytic processing of Fgf23 and increased active Fgf23 levels in serum (TableĀ 2) (White et al. 2001).
Positive_regulation (increased) of Gene_expression (levels) of Fgf23 associated with rickets
4) Confidence 0.45 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.45 Pain Relevance 0
Active vitamin D produced in the kidney increases the expression of Fgf23 in the bone and serum Fgf23 levels in mice.
Positive_regulation (increases) of Gene_expression (expression) of Fgf23 in kidney
5) Confidence 0.42 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.14 Pain Relevance 0.09
Both PTH and 1,25-(OH)2D increase FGF23 production, which helps to reduce the Pi load induced by increased intestinal Pi absorption and bone resorption associated with elevated levels of the two former hormones.
Positive_regulation (increase) of Gene_expression (production) of FGF23 associated with hypercalcemia
6) Confidence 0.40 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.50 Pain Relevance 0
Fgf23 mutations in ADHR result in impaired proteolytic processing of Fgf23 and increased active Fgf23 levels in serum (TableĀ 2) (White et al. 2001).
Positive_regulation (increased) of Gene_expression (levels) of Fgf23 associated with rickets
7) Confidence 0.39 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.44 Pain Relevance 0

General Comments

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