INT135892

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.23
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn2) plasma membrane (Accn2)
Anatomy Link Frequency
horizontal cells 1
photoreceptors 1
muscle 1
DRG 1
Accn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 99.16 Very High Very High Very High
Hyperalgesia 11 97.84 Very High Very High Very High
ASIC 14 95.32 Very High Very High Very High
PcTx1 2 79.60 Quite High
Mechanotransduction 3 78.12 Quite High
Visceral pain 2 69.92 Quite High
IPN 1 65.92 Quite High
Root ganglion neuron 1 54.36 Quite High
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.16 Very High Very High Very High
Hyperalgesia 11 97.84 Very High Very High Very High
Ganglion Cysts 5 95.08 Very High Very High Very High
Injury 3 80.64 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 69.92 Quite High
Targeted Disruption 1 67.24 Quite High
Acidosis 1 48.76 Quite Low
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, peripherally located ASIC1 and ASIC3 play different roles in the development of hyperalgesia after muscle inflammation.
Localization (located) of ASIC1 in muscle associated with hyperalgesia and inflammation
1) Confidence 0.74 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.79 Pain Relevance 1.44
QPCR of whole thoracolumbar DRG revealed and abundance of ASIC2 > ASIC1 > ASIC3.
Localization (abundance) of ASIC1 in DRG
2) Confidence 0.71 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.34
In situ hybridization and immunohistochemistry localized ASIC1a in the outer and inner nuclear layers (cone photoreceptors, horizontal cells, some amacrine and bipolar cells) and in the ganglion cell layer.
Localization (localized) of ASIC1a in photoreceptors associated with ganglion cysts
3) Confidence 0.65 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16723538 Disease Relevance 0.18 Pain Relevance 0.17
In situ hybridization and immunohistochemistry localized ASIC1a in the outer and inner nuclear layers (cone photoreceptors, horizontal cells, some amacrine and bipolar cells) and in the ganglion cell layer.
Localization (localized) of ASIC1a in horizontal cells associated with ganglion cysts
4) Confidence 0.22 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16723538 Disease Relevance 0.18 Pain Relevance 0.17

General Comments

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