INT135899

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.22
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
macrophage 2
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 16 100.00 Very High Very High Very High
cINOD 8 98.42 Very High Very High Very High
agonist 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 15 99.36 Very High Very High Very High
INFLAMMATION 3 98.14 Very High Very High Very High
Atherosclerotic Plaque 3 80.88 Quite High
Alzheimer's Dementia 10 75.00 Quite High
Increased Venous Pressure Under Development 3 75.00 Quite High
Rupture 1 62.24 Quite High
Stress 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, non-steroidal anti-inflammatory drugs (NSAIDs) and HMG-CoA reductase inhibitors (statins), two classes of drugs reported to affect APP processing and Abeta formation in Alzheimer's disease, have been evaluated for their capacity to inhibit macrophage activation evoked by platelet phagocytosis.
Regulation (affect) of Abeta Binding (formation) of in macrophage associated with inflammation, cinod, disease and abeta
1) Confidence 0.45 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 0.99 Pain Relevance 0.49
The homodimerization of APP has been previously suggested to positively regulate A?
Regulation (regulate) of APP Binding (homodimerization) of
2) Confidence 0.44 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
However, most of the other inhibitors show no inhibitory effect on the formation of the intermediate Abeta(46), but rather inhibit the turnover of Abeta(46), resulting in its accumulation.
Neg (no) Regulation (effect) of Abeta Neg (no) Binding (formation) of associated with abeta
3) Confidence 0.11 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17241131 Disease Relevance 0.16 Pain Relevance 0.65

General Comments

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