INT13590

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Context Info
Confidence 0.42
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.36
Pain Relevance 4.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
medulla 4
NTS 2
ganglia 2
nucleus 2
dopaminergic neurons 2
Nts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 10 100.00 Very High Very High Very High
Rostroventromedial medulla 5 100.00 Very High Very High Very High
noradrenaline 2 100.00 Very High Very High Very High
tetrodotoxin 4 99.84 Very High Very High Very High
Inflammation 17 99.72 Very High Very High Very High
antagonist 6 99.10 Very High Very High Very High
agonist 51 98.84 Very High Very High Very High
Enkephalin 21 98.72 Very High Very High Very High
Clonidine 3 98.48 Very High Very High Very High
Visceral pain 2 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 1 99.96 Very High Very High Very High
INFLAMMATION 18 99.72 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 97.16 Very High Very High Very High
Nociception 48 87.68 High High
Urological Neuroanatomy 15 86.72 High High
Pain 61 50.00 Quite Low
Peripheral Arterial Disease 2 7.48 Low Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Inflammatory Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localization of neurotensin binding sites to submucosal ganglia is consistent with observations that neurotensin effects on active anion secretion by the mucosa are blocked by tetrodotoxin.
Negative_regulation (blocked) of Localization (secretion) of neurotensin in ganglia associated with tetrodotoxin
1) Confidence 0.42 Published 1990 Journal Synapse Section Abstract Doc Link 2169072 Disease Relevance 0 Pain Relevance 0.10
Cromoglycate and benzalkoniumchloride, a 48/80 antagonist, both produced a progressive dose-dependent inhibition of beta-endorphin-, neurotensin- as well as compound 48/80-induced histamine release.
Negative_regulation (inhibition) of Localization (release) of neurotensin associated with antagonist
2) Confidence 0.38 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2469022 Disease Relevance 0 Pain Relevance 0.36
The dihydropyridine Ca2+ channel blocking agent, nifedipine, was without effect, but Cd2+ in the external medium blocked EJCo and also, by an effect apparently 'upstream' of varicosities, inhibited EJCi (i.e. release within the patch) but not the NTS.
Negative_regulation (inhibited) of Localization (release) of NTS in NTS associated with increased venous pressure under development
3) Confidence 0.36 Published 1989 Journal Acta Physiol. Scand. Section Abstract Doc Link 2564719 Disease Relevance 0.10 Pain Relevance 0.72
For NTS recordings, the electrode was lowered into the caudal medulla above the rostral NTS located 2.7?
Negative_regulation (lowered) of Localization (located) of NTS in medulla associated with medulla
4) Confidence 0.36 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2967336 Disease Relevance 0 Pain Relevance 0.10
Seven days after inflammation was induced, neurotensin release declined precipitously, while basal Met-enkephalin release remained elevated 313% above controls.
Negative_regulation (declined) of Localization (release) of neurotensin associated with inflammation and enkephalin
5) Confidence 0.29 Published 1995 Journal Brain Res. Section Abstract Doc Link 8535838 Disease Relevance 1.04 Pain Relevance 1.59
It is concluded that neurotensin inhibits prolactin release by a CNS, presumably hypothalamic action, to stimulate the tuberoinfundibular dopaminergic neurons.
Negative_regulation (inhibits) of Localization (release) of neurotensin in dopaminergic neurons
6) Confidence 0.28 Published 1982 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 6820240 Disease Relevance 0 Pain Relevance 0.19
The electrically stimulated release of [3H]noradrenaline ([3H]NA) from slices of the nucleus tractus solitarii (NTS) from the rat in vitro was inhibited by the alpha 2-adrenoceptor agonist, clonidine, in a concentration-dependent manner and enhanced by the alpha 2-adrenoceptor antagonist, yohimbine.
Negative_regulation (inhibited) of Localization (release) of NTS in nucleus associated with antagonist, agonist, noradrenaline and clonidine
7) Confidence 0.25 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1674475 Disease Relevance 0 Pain Relevance 0.51
Similarly, i.t. or intra-rostroventromedial medulla (RVM) administration of both selective NTS2 analogs, levocabastine and ?
Negative_regulation (medulla) of Localization (administration) of NTS2 in medulla associated with rostroventromedial medulla
8) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.07 Pain Relevance 1.01

General Comments

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