INT135909

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.94
Pain Relevance 11.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) cell adhesion (Ephb1)
plasma membrane (Ephb1) kinase activity (Ephb1) cytoplasm (Ephb1)
Anatomy Link Frequency
nerve 5
spinal cord 1
Ephb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 77 99.86 Very High Very High Very High
Desipramine 32 99.84 Very High Very High Very High
cocaine 12 99.82 Very High Very High Very High
Morphine 287 99.40 Very High Very High Very High
Spinal cord 14 98.96 Very High Very High Very High
sodium channel 7 98.92 Very High Very High Very High
opioid receptor 56 98.42 Very High Very High Very High
local anesthetic 12 98.42 Very High Very High Very High
Nav1.7 7 98.32 Very High Very High Very High
addiction 266 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 182 99.80 Very High Very High Very High
Opiate Addiction 77 98.08 Very High Very High Very High
Pain 70 96.20 Very High Very High Very High
Convulsion 13 95.68 Very High Very High Very High
Neuropathic Pain 294 95.44 Very High Very High Very High
Morphine Dependence 189 94.28 High High
Hyperalgesia 294 90.36 High High
Handedness 12 87.60 High High
Targeted Disruption 70 85.96 High High
Injury 42 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, chronic morphine treatment causes significant upregulation of EphB receptor protein in mice spinal cord, while expression of ephrinBs (ephrinB1, ephrinB2, and PY99) remains unchanged [27].
Positive_regulation (upregulation) of EphB in spinal cord associated with spinal cord and morphine
1) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.23 Pain Relevance 1.16
We have recently shown that ephrinBs and EphB receptor proteins are upregulated and redistributed in DRG and DH after nerve injury [28,29], EphB receptor proteins upregulated in DH after chronic morphine treatment [27], and activation of EphB receptors is required for the development of neuropathic pain [28,29] and morphine dependence [27].
Positive_regulation (upregulated) of EphB in nerve associated with addiction, nervous system injury, neuropathic pain, dorsal horn and morphine
2) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.40 Pain Relevance 1.71
It remains unknown how the EphB receptors, which are upregulated in DRG and DH after nerve injury, regulate the DRG neuron excitability.
Positive_regulation (upregulated) of EphB in nerve associated with nervous system injury and dorsal horn
3) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.88 Pain Relevance 0.75
Upregulation and redistribution of ephrinBs in DRG and DH [28,29] may be initiated/regulated by the nerve injury, but probably also caused by increased reverse signaling mediated by EphB receptors in DRG and/or DH where EphB receptor proteins are upregulated after nerve injury [28,29].
Positive_regulation (upregulated) of EphB in nerve associated with nervous system injury and dorsal horn
4) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.35 Pain Relevance 1.23
Upregulation and redistribution of the EphB receptors in the DH after nerve injury [28,29] or prolonged MOR activation [27] may initiate a cascade of postsynaptic effects, starting with EphB receptor activation, then intracellular signaling through Src-family kinases[51,61], and resulting in NMDA receptor activation [1-4,6-12] with Ca2+ influx through the NMDA receptor ion-channel complex.
Positive_regulation (activation) of EphB in nerve associated with nervous system injury, nmda receptor, dorsal horn and opioid receptor
5) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.97 Pain Relevance 0.93
We have recently shown that ephrinBs and EphB receptor proteins are upregulated and redistributed in DRG and DH after nerve injury [28,29], EphB receptor proteins upregulated in DH after chronic morphine treatment [27], and activation of EphB receptors is required for the development of neuropathic pain [28,29] and morphine dependence [27].
Positive_regulation (upregulated) of EphB in nerve associated with addiction, nervous system injury, neuropathic pain, dorsal horn and morphine
6) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 1.27 Pain Relevance 1.61
One possibility is that activation of the EphB1 receptor may modulate the sodium channel Nav1.7 via regulation of the small G-protein Ras-ERK-mitogen activated protein kinase (MAPK) pathway [29,68-74].
Positive_regulation (activation) of EphB1 associated with sodium channel and nav1.7
7) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.74 Pain Relevance 0.63
The co-administration of local anesthetics with desipramine reversed the behavioral sensitization and down-regulation of NET function induced by desipramine.
Positive_regulation (induced) of NET associated with desipramine and local anesthetic
8) Confidence 0.47 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17981365 Disease Relevance 0.09 Pain Relevance 0.81
Repeated administration of cocaine induces up-regulation of hippocampal NET function.
Positive_regulation (up-regulation) of NET associated with cocaine
9) Confidence 0.44 Published 2006 Journal Brain Res. Section Abstract Doc Link 16725121 Disease Relevance 0.38 Pain Relevance 1.44
These results suggest that down-regulation of hippocampal NET induced by chronic administration of desipramine may be relevant to desipramine-induced sensitization of lidocaine convulsions.
Positive_regulation (induced) of NET associated with desipramine, convulsion and lidocaine
10) Confidence 0.41 Published 2006 Journal Brain Res. Section Abstract Doc Link 16725121 Disease Relevance 0.42 Pain Relevance 1.50
We also found that Sert expression is independent of EphB1.
Positive_regulation (independent) of EphB1
11) Confidence 0.35 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.21 Pain Relevance 0

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