INT135918

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 1.46
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC5A8) transmembrane transport (SLC5A8)
Anatomy Link Frequency
oocytes 2
SLC5A8 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 6 75.00 Quite High
cINOD 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 12 100.00 Very High Very High Very High
Cancer 18 98.16 Very High Very High Very High
INFLAMMATION 2 94.24 High High
Adenocarcinoma 6 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SLC5A8 expression was reactivated by treatment with aza-deoxycytidine or trichostatin A.
Gene_expression (expression) of SLC5A8
1) Confidence 0.78 Published 2008 Journal Pancreas Section Body Doc Link 18437076 Disease Relevance 0.15 Pain Relevance 0
Because SLC5A8 is regarded as a potential tumor suppressor gene that is down-regulated by epigenetic changes in several other cancers, we sought to characterize promoter methylation status and its relationship to SLC5A8 expression in pancreatic cancer.
Gene_expression (expression) of SLC5A8 associated with cancer and pancreatic cancer
2) Confidence 0.78 Published 2008 Journal Pancreas Section Abstract Doc Link 18437076 Disease Relevance 0.53 Pain Relevance 0.07
RESULTS: Complete or partial loss of SLC5A8 expression was observed in all tumor tissues.
Gene_expression (expression) of SLC5A8
3) Confidence 0.78 Published 2008 Journal Pancreas Section Body Doc Link 18437076 Disease Relevance 0.16 Pain Relevance 0
Bisulfite sequencing analysis on pancreatic cancer cell lines that did not express SLC5A8 detected dense methylation of the promoter region.
Neg (not) Gene_expression (express) of SLC5A8
4) Confidence 0.78 Published 2008 Journal Pancreas Section Body Doc Link 18437076 Disease Relevance 0.15 Pain Relevance 0
CONCLUSIONS: Our findings indicate loss of SLC5A8 expression as a result of aberrant promoter methylation in pancreatic adenocarcinoma.
Gene_expression (expression) of SLC5A8
5) Confidence 0.78 Published 2008 Journal Pancreas Section Body Doc Link 18437076 Disease Relevance 0.12 Pain Relevance 0
METHODS: Promoter methylation and expression of SLC5A8 were evaluated in pancreatic cancer cell lines, tumor, and adjacent nontumor tissues from pancreatic cancer patients using methylation-specific polymerase chain reaction analysis, quantitative real-time and semiquantitative reverse transcriptase-polymerase chain reaction, and bisulfate-modified sequencing.
Gene_expression (expression) of SLC5A8
6) Confidence 0.78 Published 2008 Journal Pancreas Section Body Doc Link 18437076 Disease Relevance 0.19 Pain Relevance 0
However, there was no uptake of [3H]-ibuprofen into oocytes expressing hSMCT1, although the uptake of [14C]-nicotinate was demonstrable under identical conditions.
Gene_expression (expressing) of hSMCT1 in oocytes
7) Confidence 0.72 Published 2006 Journal Pharm. Res. Section Body Doc Link 16729224 Disease Relevance 0.06 Pain Relevance 0
METHODS: We expressed hSMCT1 in a mammalian cell line and in Xenopus laevis oocytes and used the uptake of nicotinate and propionate-induced currents to monitor its transport function, respectively.
Gene_expression (expressed) of hSMCT1 in oocytes
8) Confidence 0.72 Published 2006 Journal Pharm. Res. Section Body Doc Link 16729224 Disease Relevance 0.09 Pain Relevance 0

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