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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.93
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde4b) nucleus (Pde4b) cytoplasm (Pde4b)
Anatomy Link Frequency
lymphocyte 1
cerebral cortex 1
Pde4b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 62 99.98 Very High Very High Very High
antidepressant 10 98.20 Very High Very High Very High
cerebral cortex 3 97.86 Very High Very High Very High
Hippocampus 13 95.32 Very High Very High Very High
Desipramine 2 86.12 High High
addiction 2 84.24 Quite High
fluoxetine 1 76.72 Quite High
Potency 10 75.88 Quite High
Serotonin 1 62.72 Quite High
headache 4 38.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 66 99.98 Very High Very High Very High
Schizophrenia 6 98.52 Very High Very High Very High
Targeted Disruption 25 93.52 High High
Pneumonia 14 79.20 Quite High
Disease 11 70.72 Quite High
Cognitive Disorder 94 68.60 Quite High
Emphysema 6 53.52 Quite High
Pulmonary Disease 38 51.72 Quite High
Vomiting 10 40.40 Quite Low
Headache 4 38.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, treatment with combined PDE4B/4D and 7A AONs also resulted in significant inhibition of lymphocyte recruitment (data not shown).
PDE4B/4D Binding (combined) of in lymphocyte
1) Confidence 0.34 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.25 Pain Relevance 0.07
Sustained anti-inflammatory activity of PDE4B/4D and PDE7A AON following once a week treatment in cigarette smoke-exposed mice
PDE4B/4D Binding (activity) of associated with inflammation
2) Confidence 0.34 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.18 Pain Relevance 0.13
In cerebral cortex, antidepressants increased PDE4A and did not change PDE4B, whereas ROL did not change PDE4A and increased PDE4B. 3H-Rolipram binding was increased in cytosolic, but not in membrane, fractions of cerebral cortex by all drugs tested; there were no changes observed in hippocampus.
PDE4B Binding (binding) of in cerebral cortex associated with antidepressant, hippocampus and cerebral cortex
3) Confidence 0.29 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.84
Whereas ablation of PDE4A or PDE4B had no effect, inactivation of the PDE4D gene prevented co-IP of PDE activity with the ?
PDE4B Binding (ablation) of
4) Confidence 0.25 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
The same probably holds for PDE4B and memory (Ahmed and Frey 2005) or schizophrenia (Siuciak et al. 2008a).
PDE4B Binding (holds) of associated with schizophrenia
5) Confidence 0.13 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.50 Pain Relevance 0.18

General Comments

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