INT135929

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.09
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde4b) nucleus (Pde4b) cytoplasm (Pde4b)
Anatomy Link Frequency
cerebral cortex 1
hippocampus 1
Pde4b (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 16 99.98 Very High Very High Very High
Hippocampus 8 99.64 Very High Very High Very High
cerebral cortex 6 98.06 Very High Very High Very High
Desipramine 4 94.76 High High
fluoxetine 2 85.36 High High
addiction 2 82.56 Quite High
chemokine 4 76.24 Quite High
cytokine 2 75.64 Quite High
Serotonin 2 61.04 Quite High
Inflammation 31 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5 94.60 High High
Pneumonia 7 50.00 Quite Low
Exsanguination 1 41.60 Quite Low
Overdose 1 39.36 Quite Low
INFLAMMATION 33 20.88 Low Low
Pulmonary Disease 19 18.88 Low Low
Asthma 4 5.00 Very Low Very Low Very Low
Vomiting 3 5.00 Very Low Very Low Very Low
Emphysema 3 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In hippocampus, antidepressants increased PDE4A and decreased PDE4B, whereas ROL decreased PDE4A and did not change PDE4B.
Positive_regulation (increased) of PDE4B in hippocampus associated with antidepressant and hippocampus
1) Confidence 0.47 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.79
AON sequences were designed to specifically target the mRNA for human PDE4B/4D and synthesized with a phosphorothioate backbone.
Positive_regulation (target) of PDE4B/4D
2) Confidence 0.42 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.09 Pain Relevance 0.08
In cerebral cortex, antidepressants increased PDE4A and did not change PDE4B, whereas ROL did not change PDE4A and increased PDE4B. 3H-Rolipram binding was increased in cytosolic, but not in membrane, fractions of cerebral cortex by all drugs tested; there were no changes observed in hippocampus.
Neg (not) Positive_regulation (increased) of PDE4B in cerebral cortex associated with antidepressant, hippocampus and cerebral cortex
3) Confidence 0.41 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.84

General Comments

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