INT13593

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Context Info
Confidence 0.36
First Reported 1980
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 13
Total Number 20
Disease Relevance 4.35
Pain Relevance 9.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Prss12)
Anatomy Link Frequency
brain 6
interneuron 3
intervertebral space 1
neurons 1
frontal cortex 1
Prss12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 375 100.00 Very High Very High Very High
Dopamine 33 100.00 Very High Very High Very High
interneuron 11 100.00 Very High Very High Very High
5HT 9 99.76 Very High Very High Very High
antagonist 45 99.64 Very High Very High Very High
opiate 6 99.56 Very High Very High Very High
analgesia 72 98.92 Very High Very High Very High
gABA 3 98.56 Very High Very High Very High
antinociception 64 98.34 Very High Very High Very High
isoflurane 8 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 9 99.28 Very High Very High Very High
Urological Neuroanatomy 27 98.98 Very High Very High Very High
Peptic Ulcer 6 98.68 Very High Very High Very High
Hypothermia 18 98.48 Very High Very High Very High
Pain 488 97.76 Very High Very High Very High
INFLAMMATION 120 96.44 Very High Very High Very High
Inflammatory Pain 32 95.24 Very High Very High Very High
Nociception 360 89.92 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

16 87.56 High High
Ganglion Cysts 40 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that, in the rat frontal cortex, NT regulates 5HT release through a high affinity NT receptor not associated with 5HT terminals.
NT Binding (associated) of in frontal cortex associated with 5ht and urological neuroanatomy
1) Confidence 0.36 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9845009 Disease Relevance 0.23 Pain Relevance 0.46
These results suggest that in the rat striatum, NT regulates cholinergic interneuron activity by interacting with NT receptors associated with cholinergic elements.
NT Binding (interacting) of in interneuron associated with interneuron
2) Confidence 0.29 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1899109 Disease Relevance 0 Pain Relevance 0.28
These results suggest that in the rat striatum, NT regulates cholinergic interneuron activity by interacting with NT receptors associated with cholinergic elements.
NT Binding (associated) of in interneuron associated with interneuron
3) Confidence 0.29 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1899109 Disease Relevance 0 Pain Relevance 0.28
These results suggest that in the rat striatum, NT regulates cholinergic interneuron activity by interacting with NT receptors associated with cholinergic elements.
NT Binding (interacting) of in interneuron associated with interneuron
4) Confidence 0.25 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1899109 Disease Relevance 0 Pain Relevance 0.29
The results show that NT receptors in homogenates from newborn mouse and rat brain and from COS 7 cells transfected with the cloned high-affinity NT receptor from the adult rat brain displayed virtually identical structure-activity relationships toward a series of 12 peptide and pseudopeptide NT analogs, as assessed by the ability of the compounds to inhibit the binding of [125I]NT binding in these systems.
NT Binding (binding) of in brain
5) Confidence 0.16 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8301574 Disease Relevance 0 Pain Relevance 0.33
The results show that NT receptors in homogenates from newborn mouse and rat brain and from COS 7 cells transfected with the cloned high-affinity NT receptor from the adult rat brain displayed virtually identical structure-activity relationships toward a series of 12 peptide and pseudopeptide NT analogs, as assessed by the ability of the compounds to inhibit the binding of [125I]NT binding in these systems.
NT Binding (binding) of in brain
6) Confidence 0.16 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8301574 Disease Relevance 0 Pain Relevance 0.33
Furthermore, when eight of these analogs were tested for their ability to inhibit [125I]NT binding and to potentiate K(+)-evoked DA release in primary cultures of rat mesencephalic neurons, it was found that they all behaved as agonists with binding and biological potencies quite similar to those observed in the other binding assays.
NT Binding (binding) of in neurons associated with dopamine and agonist
7) Confidence 0.16 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8301574 Disease Relevance 0 Pain Relevance 0.35
Thus an interaction between brain DA systems and NT appears likely.
NT Binding (interaction) of in brain associated with dopamine
8) Confidence 0.16 Published 1980 Journal Brain Res. Section Abstract Doc Link 6446951 Disease Relevance 0.72 Pain Relevance 0.67
NT-like immunoreactivity (NT-LI) was measured with an antiserum that specifically recognizes intact NT.
NT Binding (recognizes) of
9) Confidence 0.15 Published 1991 Journal Regul. Pept. Section Abstract Doc Link 1674614 Disease Relevance 0 Pain Relevance 0.38
These data indicate that NT-induced hypothermia is not dependent on intact functional activity of NE, 5-HT, muscarinic ACh or endogenous opiate systems but suggests interactions between brain DA circuits and NT.
NT Binding (interactions) of in brain associated with hypothermia, dopamine and opiate
10) Confidence 0.12 Published 1980 Journal Brain Res. Section Abstract Doc Link 6446951 Disease Relevance 0.71 Pain Relevance 0.67
These data indicate that NT-induced cytoprotection is not mediated by 5-HT, GABA, ACh (muscarinic) receptors, or endogenous opiate systems, but suggest interactions between brain DA systems and NT.
NT Binding (interactions) of in brain associated with dopamine, gaba and opiate
11) Confidence 0.10 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2859609 Disease Relevance 0.12 Pain Relevance 0.92
Neurotensin (NT) and bombesin, which are heterogeneously distributed in both brain and gastrointestinal tissue of several mammalian species, inhibit the formation of stress-induced gastric ulcers in rats.
NT Neg (inhibit) Binding (inhibit) of in brain associated with stress and peptic ulcer
12) Confidence 0.09 Published 1983 Journal J. Neurosci. Res. Section Abstract Doc Link 6302295 Disease Relevance 0.63 Pain Relevance 0.08
The non-peptide compound levocabastine (IC50 = 3 ± 1 nM) was as potent as unlabeled NT (IC50 = 9 ± 2 nM) in inhibiting [3H]-NT binding to HEK293 cell membranes expressing NTS2.
NT Binding (binding) of
13) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.05 Pain Relevance 0.13
Furthermore, i.c.v. administration of the NT antagonist SR142948A, which recognizes both high- and low-affinity NT sites, blocked NT-induced analgesia, whereas the relative selective NTS1 antagonist SR48692 did not [14,20-22].
NT Binding (recognizes) of associated with antagonist and analgesia
14) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.14 Pain Relevance 0.99
To this end, rats were lightly anesthetized with isoflurane (Abbott Laboratories, Montreal, QC, Canada) and injected intrathecally, at the L5-L6 intervertebral space, with either NT (6 ?
NT Binding (intervertebral space) of in intervertebral space associated with isoflurane
15) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.07 Pain Relevance 0.34
g per assay for rNTS2) were incubated with 2 nM [3H]-NT for 45 min at 37°C in the binding buffer (50 mM Tris-HCl, pH 7.4, containing 1 mM EDTA, 40 ?
NT Binding (binding) of
16) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0 Pain Relevance 0.03
The earliest indication was that the analgesic effectiveness of a panel of metabolically stable peptide and pseudopeptide analogs of NT did not correlate with their binding affinities for NTS1 [13,14].
NT Neg (not) Binding (affinities) of associated with analgesic
17) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.06 Pain Relevance 0.99
The involvement of additional receptors is indeed suggested by the finding that the reversal by SR48692 of the antinociception produced by PD149163 was more complete than of that induced by NT69L, a peptidase resistant NT analog which binds to both NTS1 and NTS2 receptors with high affinity, but in a non-selective manner [37].
resistant NT Binding (binds) of associated with antinociception
18) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.85 Pain Relevance 1.08
We first demonstrated that spinally administered NT and NT69L agonists, which bind to both NTS1 and NTS2 receptors, significantly reduced pain-evoked responses during the inflammatory phase of the formalin test.
NT Binding (bind) of associated with pain, inflammation and agonist
19) Confidence 0.04 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2714839 Disease Relevance 0.52 Pain Relevance 0.77
Specific binding was calculated as the difference between total binding (zero competing compound) and nonspecific binding (excess competing compound) and the IC50 values were determined from inhibition curves as the unlabeled ligand concentration inhibiting 50% of [3H]-NT-specific binding.
NT Binding (binding) of
20) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0 Pain Relevance 0

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