INT135930

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.52
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Anatomy Link Frequency
brain 2
lung 2
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory marker 2 99.64 Very High Very High Very High
antidepressant 16 98.88 Very High Very High Very High
Hippocampus 8 98.72 Very High Very High Very High
Desipramine 4 98.12 Very High Very High Very High
fluoxetine 2 88.72 High High
cerebral cortex 6 88.56 High High
Inflammation 40 80.60 Quite High
fibrosis 47 62.64 Quite High
addiction 2 60.96 Quite High
Serotonin 2 39.44 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 42 99.64 Very High Very High Very High
Fibrosis 20 62.64 Quite High
Pneumonia 7 60.04 Quite High
Pulmonary Fibrosis 28 50.00 Quite Low
Disease 4 5.00 Very Low Very Low Very Low
Pulmonary Disease 3 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Interstitial Lung Diseases 1 5.00 Very Low Very Low Very Low
Chemotherapy-induced Neutropenia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By contrast, these treatments affected PDE4A and PDE4B expression differentially.
Regulation (affected) of Gene_expression (expression) of PDE4A
1) Confidence 0.61 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.76
Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: comparison with rolipram.
Regulation (Regulation) of Gene_expression (expression) of PDE4 in brain associated with antidepressant
2) Confidence 0.44 Published 2006 Journal Brain Res. Section Title Doc Link 16730340 Disease Relevance 0 Pain Relevance 0.61
Effect of PDE4 inhibition on lung inflammatory markers
Regulation (Effect) of Gene_expression (inhibition) of PDE4 in lung associated with inflammatory marker
3) Confidence 0.21 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.52 Pain Relevance 0.26

General Comments

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