INT13594

Context Info Confidence 0.30 First Reported 1991 Last Reported 1997 Negated 5 Speculated 0 Reported most in Abstract Documents 5 Total Number 7 Disease Relevance 1.55 Pain Relevance 4.88

peptidase activity (Prss12)

Anatomy Link Frequency PAG 6 Prss12 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Opioid 21 100.00 tetrodotoxin 2 99.82 Morphine 6 99.60 GABAergic 3 99.60 agonist 14 99.28 Dopamine 2 98.80 Serotonin 2 98.54 Calcitonin gene-related peptide 2 98.16 gABA 11 98.08 antinociception 3 97.36

Disease Link Frequency Relevance Heat Urological Neuroanatomy 27 99.68 Pain 3 87.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

G-amino-n-butyric acid (GABA), histamine, serotonin and dopamine administered at final concentrations up to 10(-5) M had no effect on NT-LI release.

Neg (no) Regulation (effect) of Localization (release) of NT associated with dopamine, gaba and serotonin

1) Confidence 0.30 Published 1991 Journal Regul. Pept. Section Abstract Doc Link 1674614 Disease Relevance 0 Pain Relevance 0.65

The nicotinic receptor agonist DMPP (10(-4) M) had no significant effect on NT-LI release.

Neg (no) Regulation (effect) of Localization (release) of NT associated with agonist

2) Confidence 0.30 Published 1991 Journal Regul. Pept. Section Abstract Doc Link 1674614 Disease Relevance 0 Pain Relevance 0.45

Tetrodotoxin did not modify the bombesin-induced release of PYY, GLP-1, and NT.

Neg (not) Regulation (modify) of Localization (release) of NT associated with tetrodotoxin

3) Confidence 0.05 Published 1995 Journal Endocrinology Section Abstract Doc Link 7588257 Disease Relevance 0 Pain Relevance 0.31

The beta-adrenergic agonist isoproterenol at a concentration of 10(-6) M induced a transient rise in portal PYY and GLP-1 concentrations, whereas the effect on NT release was clearly biphasic.

Regulation (effect) of Localization (release) of NT associated with agonist

4) Confidence 0.05 Published 1995 Journal Endocrinology Section Abstract Doc Link 7588257 Disease Relevance 0 Pain Relevance 0.33

However, local administration in the PAG of the GABA(A) antagonist bicuculline (0.1-10 microM) or the GABA(A) agonist muscimol (1-100 microM) had no significant effect on the extracellular NT-LI level in the PAG, suggesting that GABAergic mechanisms are not involved in the opioid-induced release of NT-LI.

Neg (not) Regulation (involved) of Localization (release) of NT in PAG associated with gaba, gabaergic, antagonist, agonist, urological neuroanatomy and opioid

5) Confidence 0.04 Published 1997 Journal Brain Res. Section Abstract Doc Link 9452203 Disease Relevance 0.39 Pain Relevance 1.00

In the present microdialysis study, the effect of opioids on the release of NT in the ventromedial PAG was investigated.

Regulation (effect) of Localization (release) of NT in PAG associated with urological neuroanatomy and opioid

6) Confidence 0.04 Published 1997 Journal Brain Res. Section Abstract Doc Link 9452203 Disease Relevance 0.60 Pain Relevance 1.00

Perfusion of the microdialysis probe with 10 microM morphine induced a significant increase (P < 0.05; n = 5) of the extracellular level of NT-like immunoreactivity (NT-LI), while perfusion with a 10-fold higher concentration of morphine had no significant effect on the NT-LI release in the PAG.

Neg (no) Regulation (effect) of Localization (release) of NT in PAG associated with urological neuroanatomy and morphine

7) Confidence 0.04 Published 1997 Journal Brain Res. Section Abstract Doc Link 9452203 Disease Relevance 0.56 Pain Relevance 1.15

General Comments

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