INT135941

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.80
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE2A, PRKG1) signal transduction (PDE2A, PRKG1) plasma membrane (PDE2A, PRKG1)
cytoplasm (PDE2A, PRKG1) Golgi apparatus (PDE2A) endoplasmic reticulum (PDE2A)
Anatomy Link Frequency
colon 3
PDE2A (Homo sapiens)
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 90.44 High High
agonist 1 75.52 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 5 98.36 Very High Very High Very High
Apoptosis 2 97.92 Very High Very High Very High
Solid Tumor 1 96.04 Very High Very High Very High
Death 2 90.48 High High
INFLAMMATION 1 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In colon cancer cells, the antineoplastic effects of exisulind have been attributed, in part, to induction of cyclic guanosine 3',5'-monophosphate (cGMP) signaling through inhibition of cGMP-specific phosphodiesterases, which elevates intracellular cGMP, and novel expression of cGMP-dependent protein kinase (PKG) Ibeta, the presumed downstream effector mediating apoptosis.
Positive_regulation (induction) of cGMP in colon Positive_regulation (elevates) of Gene_expression (expression) of PKG in colon associated with colon cancer and apoptosis
1) Confidence 0.13 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.80 Pain Relevance 0.13

General Comments

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