INT135945

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE2A) signal transduction (PDE2A) Golgi apparatus (PDE2A)
endoplasmic reticulum (PDE2A) plasma membrane (PDE2A) nucleus (PDE2A)
Anatomy Link Frequency
brain 2
PDE2A (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 30 99.98 Very High Very High Very High
Glutamate 39 99.16 Very High Very High Very High
agonist 2 95.64 Very High Very High Very High
cytokine 5 89.56 High High
adenocard 1 86.48 High High
Neurotransmitter 1 80.40 Quite High
cINOD 1 64.92 Quite High
Inflammation 2 50.00 Quite Low
gABA 28 5.00 Very Low Very Low Very Low
Hippocampus 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 3 98.04 Very High Very High Very High
Colon Cancer 5 90.92 High High
Apoptosis 2 85.56 High High
Solid Tumor 1 70.52 Quite High
INFLAMMATION 3 64.72 Quite High
Post-traumatic Stress Disorder 88 50.00 Quite Low
Traumatic Stress Disorders 5 50.00 Quite Low
Neurodegenerative Disease 7 36.24 Quite Low
Stress 82 22.52 Low Low
Drug Induced Neurotoxicity 4 12.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, the antiproliferative effects of induced cGMP accumulation were paradoxically less than additive, rather than synergistic, when combined with exisulind.
Positive_regulation (induced) of Positive_regulation (accumulation) of cGMP
1) Confidence 0.12 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.78 Pain Relevance 0.11
Soluble guanylate cyclase represents the most important NO receptor in the brain (Dawson VL and Dawson TM 1995), with its activation by NO following glutamate-mediated activation of the NMDA receptor leading to an increase in the second messenger – cyclic guanosine monophosphate (cGMP) (Fedele et al 2001).
Neg (NO) Positive_regulation (leading) of Positive_regulation (increase) of cGMP in brain associated with glutamate and nmda receptor
2) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0 Pain Relevance 0.23

General Comments

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