INT135954

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.64
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Cav1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 99.98 Very High Very High Very High
antagonist 1 98.28 Very High Very High Very High
cINOD 2 66.64 Quite High
anesthesia 1 53.32 Quite High
adenocard 1 34.88 Quite Low
halothane 1 22.84 Low Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 2 92.76 High High
Apoptosis 2 76.72 Quite High
Disease 14 75.40 Quite High
Cancer 3 75.00 Quite High
Hypokalemic Periodic Paralysis 29 73.20 Quite High
INFLAMMATION 2 65.20 Quite High
Malignant Hyperthermia 8 53.76 Quite High
Channelopathies 17 50.00 Quite Low
Renal Failure 1 47.76 Quite Low
Myoglobinuria 1 46.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fast depolarization-induced conformational changes of Cav1.1 ?
Positive_regulation (induced) of Phosphorylation (changes) of Cav1
1) Confidence 0.40 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.20 Pain Relevance 0.05
At concentrations from 2.5 to 7.5 micromol/L, the PPARgamma agonists induce caveolin-1 and phosphorylation of Akt and cotreatment with the PPARgamma antagonist GW9662 inhibited the induction response.
Positive_regulation (induce) of Phosphorylation (phosphorylation) of caveolin-1 associated with antagonist and agonist
2) Confidence 0.31 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731770 Disease Relevance 0.44 Pain Relevance 0.17

General Comments

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