INT135955

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 7.73
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Anatomy Link Frequency
tibialis anterior 1
band 1
Cav1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 74 99.98 Very High Very High Very High
Kinase C 4 99.00 Very High Very High Very High
cINOD 24 98.76 Very High Very High Very High
Nav1.7 1 98.60 Very High Very High Very High
antagonist 23 98.16 Very High Very High Very High
nav1.8 1 98.16 Very High Very High Very High
Action potential 12 96.56 Very High Very High Very High
cytokine 19 96.00 Very High Very High Very High
Calcium channel 14 95.68 Very High Very High Very High
Intracerebroventricular 4 87.96 High High
Disease Link Frequency Relevance Heat
Cancer 507 99.84 Very High Very High Very High
INFLAMMATION 65 98.04 Very High Very High Very High
Dystonia 40 97.48 Very High Very High Very High
Apoptosis 105 97.36 Very High Very High Very High
Appetite Loss 21 96.16 Very High Very High Very High
Breast Cancer 275 96.00 Very High Very High Very High
Frailty 21 95.40 Very High Very High Very High
Colon Cancer 25 92.76 High High
Stress 50 92.32 High High
Ataxia 8 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the tibialis anterior of the C26 hosts we indeed detected by immunofluorescence microscopy increased levels of Pax7 and caveolin-1 (Fig. 5A), two markers of undifferentiated cells.
Positive_regulation (increased) of caveolin-1 in tibialis anterior
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.54 Pain Relevance 0
As shown in Figure 6, the electrophysiological properties of Cav1.4nob2 are not significantly different from those of Cav1.4wt when expressed in tsA-201 cells, with either 20 mM Ba2+ or 2 mM Ca2+ as charge carrier, suggesting that the differences between Cacna1fnob2 and Cacna1fwt mice do not arise from changes in the activation or inactivation characteristics of the Cav1.4 channels.
Positive_regulation (activation) of Cav1
2) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0
These results indicated that a full-length Cav1.4 channel (corresponding to the mRNA sequence from the smaller Mr, less intense band in Figure 1B) could be present in the Cacna1fnob2 mouse.
Positive_regulation (present) of Cav1 in band
3) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0.09 Pain Relevance 0.05
This was accompanied by loss of caveolin-1 induction but induction of proapoptotic nonsteroidal anti-inflammatory drug activated gene-1.
Positive_regulation (induction) of caveolin-1 associated with inflammation and cinod
4) Confidence 0.44 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731770 Disease Relevance 0.74 Pain Relevance 0.26
Further support for an isoform-specific role of Cav1.2 LTCCs in the induction of dystonic behavior comes from a mouse mutant in that a single targeted mutation within the dihydropyridine binding pocket eliminates BayK 8644 sensitivity but causes no detectable changes in Cav1.2 function and expression [68].
Neg (no) Positive_regulation (changes) of Cav1 associated with dystonia
5) Confidence 0.40 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.67 Pain Relevance 0
Biochemical studies revealed significant upregulation of Cav1.2 ?
Positive_regulation (upregulation) of Cav1
6) Confidence 0.40 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.83 Pain Relevance 0.04
These mice are completely resistant to the typical BayK 8644-induced dystonic behavior observed in wild-type mice [37], indicating that this drug effect cannot be mediated by Cav1.3 activation alone but requires Cav1.2 [68].
Positive_regulation (requires) of Cav1 associated with dystonia
7) Confidence 0.37 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.74 Pain Relevance 0
In contrast, lipoamino acids had weak effects on high-voltage-activated (HVA) Cav1.2 and Cav2.2 calcium currents, on Nav1.7 and Nav1.8 sodium currents, and on anandamide-sensitive TRPV1 and TASK1 currents.
Positive_regulation (high-voltage-activated) of Cav1 associated with nav1.8 and nav1.7
8) Confidence 0.35 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19846698 Disease Relevance 0.06 Pain Relevance 0.56
Whereas negative activation of an even small Cav1.3 current could trigger pacemaking, faster CDI would limit Ca2+ entry during ensuing action potentials.
Positive_regulation (activation) of Cav1 associated with action potential
9) Confidence 0.32 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.24 Pain Relevance 0.12
At concentrations from 2.5 to 7.5 micromol/L, the PPARgamma agonists induce caveolin-1 and phosphorylation of Akt and cotreatment with the PPARgamma antagonist GW9662 inhibited the induction response.
Positive_regulation (induce) of caveolin-1 associated with antagonist and agonist
10) Confidence 0.31 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731770 Disease Relevance 0.44 Pain Relevance 0.16
in mediating CDIM9 induction of caveolin-1 and p27, MDA-MB231 cells were treated with 10 or 20 ?
Positive_regulation (induction) of caveolin-1
11) Confidence 0.24 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.21 Pain Relevance 0.05
The greater induction of caveolin-1 compared with p27 in vivo may reflect pharmacologic barriers preventing the drug from reaching all of the tumor cells in vivo.
Positive_regulation (induction) of caveolin-1 associated with cancer
12) Confidence 0.24 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.90 Pain Relevance 0.03
activation and upregulation of the cell cycle regulating genes p27 and caveolin-1.
Positive_regulation (upregulation) of caveolin-1
13) Confidence 0.24 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.80 Pain Relevance 0
Neither p27 nor caveolin-1 was induced in BT549 cells after treatment with CDIM9 (Figure 2b).
Neg (Neither) Positive_regulation (induced) of caveolin-1
14) Confidence 0.17 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.24 Pain Relevance 0.04
Co-treatment of GW9662 inhibited the induction of caveolin-1 and p27 by CDIM9 in MDA-MB231 cells (Figure 2a), suggesting that these responses were PPAR-?
Positive_regulation (induction) of caveolin-1
15) Confidence 0.17 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.34 Pain Relevance 0.10
FAN, RACK-1 and caveolin-1) have been shown to trigger nSMase activation [5], [6].
Positive_regulation (activation) of caveolin-1
16) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.71 Pain Relevance 0.09
Though we did observe a modest effect in suppressing MCh-induced contractile force with bisindolylmaleimide and U0126 treatment, the effect was of equal magnitude on Cav-1 KO and B6129SF2/J mice, suggesting that the contribution of PKC and p42/p44 MAPK to contractile responses is not changed in Cav-1 KO mice.
Neg (not) Positive_regulation (changed) of Cav-1 KO associated with kinase c
17) Confidence 0.09 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.16 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox