INT135956

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.24
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Anatomy Link Frequency
endothelial cells 1
Cav1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 2 99.84 Very High Very High Very High
antagonist 1 98.28 Very High Very High Very High
cINOD 16 66.64 Quite High
anesthesia 1 52.40 Quite High
Kinase C 3 46.16 Quite Low
Inflammation 39 36.56 Quite Low
adenocard 1 33.96 Quite Low
halothane 1 21.92 Low Low
cytokine 6 16.44 Low Low
COX-2 inhibitor 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 26 99.04 Very High Very High Very High
Colon Cancer 68 92.48 High High
Disorder Of Lipid Metabolism 137 87.28 High High
INFLAMMATION 55 77.28 Quite High
Apoptosis 25 76.72 Quite High
Cancer 116 75.00 Quite High
Disease 15 74.48 Quite High
Hypokalemic Periodic Paralysis 29 72.28 Quite High
Targeted Disruption 13 61.92 Quite High
Experimental Melanoma 2 55.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fast depolarization-induced conformational changes of Cav1.1 ?
Phosphorylation (changes) of Cav1
1) Confidence 0.64 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.20 Pain Relevance 0.05
At concentrations from 2.5 to 7.5 micromol/L, the PPARgamma agonists induce caveolin-1 and phosphorylation of Akt and cotreatment with the PPARgamma antagonist GW9662 inhibited the induction response.
Phosphorylation (phosphorylation) of caveolin-1 associated with antagonist and agonist
2) Confidence 0.51 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731770 Disease Relevance 0.44 Pain Relevance 0.17
The tyrosine phosphorylated form of caveolin-1 colocalizes with focal adhesions, suggesting a role for caveolin-1 in migration. ?
Phosphorylation (phosphorylated) of caveolin-1 associated with adhesions
3) Confidence 0.28 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.45 Pain Relevance 0
The tyrosine phosphorylated form of caveolin-1 colocalizes with focal adhesions, suggesting a role for caveolin-1 in migration. ?
Phosphorylation (form) of caveolin-1 associated with adhesions
4) Confidence 0.28 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.45 Pain Relevance 0
These effects are achieved both through the maintenance of cholesterol content in caveolae for eNOS (Uittenbogaard et al 2000; Everson and Smart 2001) and the phosphorylation of caveolin1 (the main protein of the caveolae) and subsequent PGI-S shuttling and Cox-2 coupling in the perinuclear area of endothelial cells (Norata, Callegari, et al 2004).
Phosphorylation (phosphorylation) of caveolin1 in endothelial cells
5) Confidence 0.14 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.70 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox