INT135959

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 37
Total Number 38
Disease Relevance 21.16
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
liver 15
plasma 4
somatotroph 4
lung 4
muscle 2
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 120 100.00 Very High Very High Very High
cytokine 60 99.84 Very High Very High Very High
antagonist 41 97.96 Very High Very High Very High
ischemia 84 94.80 High High
Central nervous system 43 82.64 Quite High
Dopamine 36 81.60 Quite High
agonist 44 80.88 Quite High
Somatostatin 182 79.20 Quite High
Intracerebroventricular 3 77.88 Quite High
abdominal pain 3 76.80 Quite High
Disease Link Frequency Relevance Heat
Disease 242 100.00 Very High Very High Very High
INFLAMMATION 138 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 22 100.00 Very High Very High Very High
Frailty 90 99.96 Very High Very High Very High
Aging 897 99.78 Very High Very High Very High
Insulin Resistance 20 99.76 Very High Very High Very High
Pancreatic Cancer 10 99.62 Very High Very High Very High
Htlv Types I And Ii 3 99.58 Very High Very High Very High
Cancer 296 99.44 Very High Very High Very High
Body Weight 94 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result was surprising, since several studies have shown that IGF-I expression and protein levels decline under CR [36-38].
Negative_regulation (decline) of Gene_expression (expression) of IGF-I
1) Confidence 0.56 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.18 Pain Relevance 0
It was further surprising that of the four CR treatments, IGF-I expression was only decreased significantly when CR was applied to dwarf mice (which already exhibit IGF-I deficiency).
Negative_regulation (decreased) of Gene_expression (expression) of IGF-I
2) Confidence 0.56 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.12 Pain Relevance 0
IGF-I expression was significantly downregulated in all contrasts involving the Snell, Ames and Little dwarfs (Fig. 1, Table 2).
Negative_regulation (downregulated) of Gene_expression (expression) of IGF-I
3) Confidence 0.56 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.12 Pain Relevance 0
In this study, IGF-I production was inactivated in the liver of adult mice (LI-IGF-I(-/-)), resulting in an approximately 80-85% reduction of circulating IGF-I concentrations.
Negative_regulation (inactivated) of Gene_expression (production) of IGF-I in liver
4) Confidence 0.43 Published 2006 Journal J. Endocrinol. Section Abstract Doc Link 16731792 Disease Relevance 0.19 Pain Relevance 0.08
Even more, the suppression of the somatotroph axis and subsequent decreased IGF1 production in 15-d-old Csbm/m/Xpa?
Negative_regulation (decreased) of Gene_expression (production) of IGF1 in somatotroph
5) Confidence 0.41 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 0.35 Pain Relevance 0.03
Even more, the suppression of the somatotroph axis and subsequent decreased IGF1 production in 15-d-old Csbm/m/Xpa?
Negative_regulation (suppression) of Gene_expression (production) of IGF1 in somatotroph
6) Confidence 0.41 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 0.36 Pain Relevance 0.03
Ultimately, however, it is important to develop a systemic model of GH/IGF-I signaling, with further evaluation of the respective roles of IGF-I and GH in extended longevity.
Negative_regulation (develop) of Gene_expression (model) of IGF-I associated with aging
7) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.44 Pain Relevance 0
Several genes exhibited expression patterns among all contrasts that were positively or negatively related to IGF-I expression (Fig. 2 and Additional files 1 and 2).
Negative_regulation (related) of Gene_expression (expression) of IGF-I
8) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0 Pain Relevance 0
In fact, reduced IGF-I levels in circulation may be the main factor behind extended lifespan in dwarf mice, such that with respect to liver, the only expression change consequential for longevity determination is that of the IGF-I transcript.
Negative_regulation (reduced) of Gene_expression (levels) of IGF-I in liver associated with aging and lifespan
9) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.89 Pain Relevance 0
This results in reduced GH and IGF-I levels, as well as other hormonal abnormalities, such as deficiency of thyroid stimulating hormone and prolactin [12,13].
Negative_regulation (reduced) of Gene_expression (levels) of IGF-I in thyroid associated with congenital anomalies
10) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 1.21 Pain Relevance 0
Since we observed a reduction in liver Igf1 mRNA expression and in circulating levels of IGF1 protein, indicative of GH deficiency, and since most individuals with PWS are GH deficient, we studied the structure and development of the pituitary gland to determine whether the GH deficiency is caused by a structural pituitary defect or a reduction in the number of GH producing cells in the anterior pituitary.
Negative_regulation (reduction) of in liver Gene_expression (expression) of Igf1 in pituitary gland associated with syndrome
11) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.29 Pain Relevance 0
Whether the GH level normalizes post irradiation mainly depends on pre-irradiation serum GH concentration and the time interval between radiotherapy and the measurement of GH and IGF-1 levels.
Negative_regulation (measurement) of Gene_expression (levels) of IGF-1
12) Confidence 0.40 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.15 Pain Relevance 0
A paired, two sample t-test for means between groups demonstrated a statistically significant difference between IGF-1 and MK alone and MK plus TNF-?
Negative_regulation (difference) of Gene_expression (alone) of IGF-1
13) Confidence 0.39 Published 2003 Journal Crit Care Section Body Doc Link PMC374373 Disease Relevance 0.27 Pain Relevance 0.05
Low creatine phosphokinase level in insulin-like growth factor-1 treated hearts
Negative_regulation (Low creatine phosphokinase) of Gene_expression (level) of insulin-like growth factor-1 in hearts associated with disorders of creatine metabolism
14) Confidence 0.39 Published 2003 Journal Crit Care Section Body Doc Link PMC374373 Disease Relevance 0.28 Pain Relevance 0.05
If reduced IGF-1 mRNA correlates with increased longevity, why were liver IGF-1 mRNA levels observed here lowest in XPCS/XPA animals with the shortest lifespan and intermediate in CH/XPA mice with intermediate longevity?
Negative_regulation (liver) of Gene_expression (levels) of IGF-1 mRNA in liver associated with aging and lifespan
15) Confidence 0.38 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 1.26 Pain Relevance 0
At the end of their lives, IGF-1 levels remained within the normal range, while blood glucose levels once again fell significantly below control WT and XPA levels.
Negative_regulation (remained) of Gene_expression (levels) of IGF-1 in blood
16) Confidence 0.38 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.81 Pain Relevance 0
IGF-1 mRNA from liver, the major source of circulating IGF-1, was significantly reduced in both (Figure 4C, p < 0.05).
Negative_regulation (reduced) of Gene_expression (source) of IGF-1 in liver
17) Confidence 0.38 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.71 Pain Relevance 0
IGF-1 mRNA from liver, the major source of circulating IGF-1, was significantly reduced in both (Figure 4C, p < 0.05).
Negative_regulation (reduced) of Gene_expression (source) of IGF-1 mRNA in liver
18) Confidence 0.38 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.77 Pain Relevance 0
Fgf21 reduces concentrations of the active form of signal transducer and activator of transcription 5, a major mediator of growth hormone actions, and causes corresponding decreases in the expression of its target genes including Igf-1.
Negative_regulation (decreases) of Gene_expression (expression) of Igf-1
19) Confidence 0.38 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.65 Pain Relevance 0.05
, displays a more severe reduction in IGF1 receptor expression and exhibits a higher capacity to endure and recover from oxidant-induced lung injury than mice expressing normal levels of IGF1 receptors (Ahamed et al. 2005).
Negative_regulation (reduction) of Gene_expression (expression) of IGF1 in lung associated with lung injury
20) Confidence 0.36 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.91 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox