INT135961

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.67
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hc) extracellular region (Hc)
Anatomy Link Frequency
cardiomyocytes 1
brainstem 1
skin 1
T-cells 1
Hc (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 4 98.32 Very High Very High Very High
medulla 6 97.48 Very High Very High Very High
antagonist 3 95.92 Very High Very High Very High
intrathecal 1 93.24 High High
Intracerebroventricular 1 92.56 High High
Arthritis 40 90.64 High High
cytokine 31 88.96 High High
Clonidine 15 86.40 High High
withdrawal 21 82.48 Quite High
Inflammation 43 81.88 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 9 98.32 Very High Very High Very High
Adhesions 9 92.88 High High
Arthritis 42 90.64 High High
Hypersensitivity 9 85.52 High High
Shock 7 84.08 Quite High
Opiate Addiction 6 82.48 Quite High
Targeted Disruption 7 81.96 Quite High
INFLAMMATION 46 81.88 Quite High
Injury 28 77.84 Quite High
Sleep Disorders 63 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the authors found that the C5a receptor messenger RNA level increased 15-fold in the skin surrounding the incisions within 24 h and then slowly declined.
Positive_regulation (increased) of C5a in skin
1) Confidence 0.67 Published 2006 Journal Anesthesiology Section Body Doc Link 16732100 Disease Relevance 0.11 Pain Relevance 0
Following antigenic stimulation both DCs and T-cells upregulate C3a and C5a receptors, produce C3, alternative complement factors B and D, and downregulate CD55.
Positive_regulation (upregulate) of C5a in T-cells
2) Confidence 0.49 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.58 Pain Relevance 0.12
Recently, the upregulation of TRPC4 and C5 was shown in cardiomyocytes in response to inhibition of SERCA expression.
Positive_regulation (upregulation) of C5 in cardiomyocytes
3) Confidence 0.22 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.05 Pain Relevance 0
In this model TRPC4 and C5 seem to be induced after insufficient function of SR calcium accumulation [22].
Positive_regulation (induced) of C5
4) Confidence 0.15 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0
In this model TRPC4 and C5 seem to be induced after insufficient function of SR calcium accumulation [22].
Positive_regulation (accumulation) of C5
5) Confidence 0.15 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.05 Pain Relevance 0
Subsequently the most potent anaphylatoxin, C5a, is generated from C5 during activation of the complement system by the C5 convertase.
Positive_regulation (generated) of C5
6) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.05 Pain Relevance 0.44
The effect of HC-030031 was evidenced on the day after CFA injection and was kept throughout the test.
Positive_regulation (effect) of HC-030031
7) Confidence 0.03 Published 2010 Journal Pain Section Abstract Doc Link 20056530 Disease Relevance 0.72 Pain Relevance 0.81
The authors concluded that assessing the P.01 response to serial increases of HC levels may be a safe means to ascertain whether patients with brainstem lesions are ready for ventilator weaning.
Positive_regulation (increases) of HC in brainstem associated with medulla
8) Confidence 0.02 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2837179 Disease Relevance 0.22 Pain Relevance 0.21
VE and VT increases after HC were significantly greater in group I.
Positive_regulation (increases) of HC
9) Confidence 0.02 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2837179 Disease Relevance 0.40 Pain Relevance 0.13
The increase in P0.1 following HC was significantly greater in group I compared with group II patients.
Positive_regulation (increase) of HC
10) Confidence 0.02 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2837179 Disease Relevance 0.48 Pain Relevance 0.17

General Comments

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