INT135969

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.32
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (S100a4)
Anatomy Link Frequency
RAW 264 2
A15 1
chondrocytes 1
macrophage 1
fibroblast 1
S100a4 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 4 99.10 Very High Very High Very High
Osteoarthritis 6 98.32 Very High Very High Very High
metalloproteinase 9 97.44 Very High Very High Very High
Inflammation 260 94.36 High High
fibrosis 213 94.00 High High
cytokine 66 89.60 High High
Thoracotomy 18 86.12 High High
chemokine 33 71.12 Quite High
Inflammatory response 24 55.68 Quite High
Inflammatory mediators 3 40.84 Quite Low
Disease Link Frequency Relevance Heat
Fibrosis 123 99.44 Very High Very High Very High
Cancer 96 98.96 Very High Very High Very High
Osteoarthritis 6 98.32 Very High Very High Very High
INFLAMMATION 281 94.36 High High
Lung Injury 54 92.72 High High
Injury 30 89.52 High High
Adult Respiratory Distress Syndrome 102 88.88 High High
Pulmonary Fibrosis 144 88.60 High High
Disease 37 85.28 High High
Wound Healing 9 56.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of S100A4/FSP1 in the epithelium indicates the presence of transition from epithelial cells to fibroblasts.
Gene_expression (expression) of S100A4 in epithelial cells
1) Confidence 0.58 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 1.00 Pain Relevance 0.34
The expression of S100A4/FSP1 indicates the presence of an ongoing angiogenetic program determining the mesenchymal phenotype [16].
Gene_expression (expression) of S100A4
2) Confidence 0.58 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.50 Pain Relevance 0.18
After PNY, there was a significant (P < 0.05) increase in the percentage of total nucleated cells that were positive for S100A4, BrdU, or S100A4 in combination with BrdU (Figure 7).
Gene_expression (positive) of S100A4
3) Confidence 0.58 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.06 Pain Relevance 0.07
After PNY, there was a significant (P < 0.05) increase in the percentage of total nucleated cells that were positive for S100A4, BrdU, or S100A4 in combination with BrdU (Figure 7).
Gene_expression (positive) of S100A4
4) Confidence 0.58 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.06 Pain Relevance 0.07
However, our initial analysis shows that S100A4+ fibroblast-like cells, but not ?
Gene_expression (fibroblast) of S100A4 in fibroblast
5) Confidence 0.58 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.31 Pain Relevance 0.17
High-tidal-volume ventilation induced type I and type III procollagen mRNA expression, microvascular permeability, hydroxyproline content, Masson's trichrome staining, S100A4/fibroblast specific protein-1 staining, activation of Akt and extracellular signal-regulated kinase (ERK) 1/2, and production of macrophage inflammatory protein-2 and 10 kDa IFN?
Gene_expression (expression) of S100A4 in macrophage associated with inflammation
6) Confidence 0.45 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2575592 Disease Relevance 0.78 Pain Relevance 0.23
S100A4 is expressed in astrocytes, Schwann cells, and other neuronal cells in addition to chondrocytes [43].
Gene_expression (expressed) of S100A4 in chondrocytes
7) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.63 Pain Relevance 0.10
Ligands of RAGE: S100A4, A6, A7/A7A/A15, A11, A12, A13, B, P
Gene_expression (/) of S100A4 in A15
8) Confidence 0.13 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.59 Pain Relevance 0.09
Ligands of RAGE: S100A4, A6, A7/A7A/A15, A11, A12, A13, B, P
Gene_expression (/) of S100A4 in A11
9) Confidence 0.04 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.59 Pain Relevance 0.09
In this study we examine the inhibitory effect of a stable [6]-gingerol metabolite, RAC-[6]-dihydroparadol ([6]-DHP) and a closely related gingerol analogue, RAC-2-hydroxy-1-(4-hydroxy-3-methoxyphenyl)dodecan-3-one [a capsaicin/gingerol (Capsarol) analogue referred to as ZTX42] on NO production, inducible nitric oxide synthase (iNOS) activity and protein expression levels in a murine macrophage cell line, RAW 264.7.
Gene_expression (expression) of ZTX42 in RAW 264 associated with qutenza
10) Confidence 0.00 Published 2006 Journal Planta Med. Section Abstract Doc Link 16732525 Disease Relevance 0.41 Pain Relevance 0.22
In this study we examine the inhibitory effect of a stable [6]-gingerol metabolite, RAC-[6]-dihydroparadol ([6]-DHP) and a closely related gingerol analogue, RAC-2-hydroxy-1-(4-hydroxy-3-methoxyphenyl)dodecan-3-one [a capsaicin/gingerol (Capsarol) analogue referred to as ZTX42] on NO production, inducible nitric oxide synthase (iNOS) activity and protein expression levels in a murine macrophage cell line, RAW 264.7.
Neg (NO) Gene_expression (production) of ZTX42 in RAW 264 associated with qutenza
11) Confidence 0.00 Published 2006 Journal Planta Med. Section Abstract Doc Link 16732525 Disease Relevance 0.41 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox