INT135990

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 34
Total Number 36
Disease Relevance 12.02
Pain Relevance 4.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd86)
Anatomy Link Frequency
CD86 60
B cells 4
T-cell 4
macrophages 2
monocytes 2
Cd86 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 334 99.36 Very High Very High Very High
spastic colon 27 99.14 Very High Very High Very High
Inflammation 218 98.40 Very High Very High Very High
chemokine 69 97.66 Very High Very High Very High
Central nervous system 19 96.92 Very High Very High Very High
transdermal 5 88.92 High High
rheumatoid arthritis 80 85.68 High High
tolerance 7 80.00 Quite High
Inflammatory mediators 5 73.36 Quite High
Inflammatory response 20 69.40 Quite High
Disease Link Frequency Relevance Heat
Candida Infection 275 99.98 Very High Very High Very High
Fever 24 99.98 Very High Very High Very High
Influenza Virus Infection 19 99.56 Very High Very High Very High
Multiple Sclerosis 19 99.32 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

23 99.14 Very High Very High Very High
INFLAMMATION 228 98.40 Very High Very High Very High
Diphtheria 3 97.12 Very High Very High Very High
Cancer 382 97.10 Very High Very High Very High
Infection 231 95.68 Very High Very High Very High
Neurocysticercosis 30 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hyperthermia increases the expression of co-stimulatory molecules such as CD80 and CD86.
Positive_regulation (increases) of Gene_expression (expression) of CD86 in CD86 associated with fever
1) Confidence 0.69 Published 2006 Journal Vaccine Section Abstract Doc Link 16735086 Disease Relevance 1.11 Pain Relevance 0.18
In parallel, some of the F4/80+ cells migrated to the inner pulp of the treated side, increased in size and enhanced CD86 expression.
Positive_regulation (increased) of Gene_expression (expression) of CD86 in CD86
2) Confidence 0.53 Published 2006 Journal Int. Immunol. Section Abstract Doc Link 16849394 Disease Relevance 0.27 Pain Relevance 0.06
These results was consistent with the report from Anne Krug that CpG could promote survival of PDCs, activate purified PDCs by a rapid increase of CD80, CD86 and CD40 expression but the increased degree of CD80 was much lower than that of CD86 [37].
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
3) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.29 Pain Relevance 0
CpG-ODN, a known potent DC stimulator, induced the highest level of IL-12p70 production while only moderately increasing IL-10 production, and significantly enhanced the expression of CD80 and CD86, indicating CpG-ODN induced immature DC towards a mature phenotype.
Positive_regulation (enhanced) of Gene_expression (expression) of CD86 in CD86
4) Confidence 0.41 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.49 Pain Relevance 0.04
Vaccinated with CpG-ODN induces CD86 expression on B cells in IFN-?
Positive_regulation (induces) of Gene_expression (expression) of CD86 in B cells
5) Confidence 0.40 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.20 Pain Relevance 0.07
More importantly, 55°C-HIFU-treated tumor cells showed much more potent immunostimulatory activities than 80°C-HIFU-treated ones, both in the induction of IL-12p70 production and in the upregulation of CD80 and CD86 expression.
Positive_regulation (upregulation) of Gene_expression (expression) of CD86 in CD86 associated with cancer
6) Confidence 0.39 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.85 Pain Relevance 0.07
There may have been a slight increase in CD86 levels (Fig. 5) in cultures pretreated with vitamin C.
Positive_regulation (increase) of Gene_expression (levels) of CD86 in CD86
7) Confidence 0.38 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
In cultures pretreated with vitamin C, the levels of both CD80 and CD86 after activation were similar to the control group.
Positive_regulation (activation) of Gene_expression (levels) of CD86 in CD86
8) Confidence 0.38 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
The results showed that CpG promoted the expression of CD40 and CD86 after 24 h.
Positive_regulation (promoted) of Gene_expression (expression) of CD86 in CD86
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.05 Pain Relevance 0
However, when combination of both E2 and CpG was used, the enhancements of CD40 and CD86 expression were more strikingly than CpG alone (Figure 2 and Figure S4).
Positive_regulation (enhancements) of Gene_expression (expression) of CD86 in CD86
10) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.14 Pain Relevance 0
Amaya lparraguirre reported that although both influenza virus and CpG led to increased expression levels of costimulatory molecules on PDCs, including CD40 and CD86 as well as MHC II, an exception was CD80, which was expressed to the lower extend under the CpG stimuli than the influenza virus stimuli [38].
Positive_regulation (increased) of Gene_expression (expression) of CD86 in CD86 associated with influenza virus infection
11) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.33 Pain Relevance 0
In parallel, some of the F4/80+ cells migrated to the inner pulp of the treated side, increased in size and enhanced CD86 expression.
Positive_regulation (enhanced) of Gene_expression (expression) of CD86 in CD86
12) Confidence 0.35 Published 2006 Journal Int. Immunol. Section Abstract Doc Link 16849394 Disease Relevance 0.26 Pain Relevance 0.06
RIIb is sufficient to induce an increase in the expression of CD86 [38,39], whereas the overexpression of this receptor on murine B cells reverses the induction of CD86 triggered via BCR [9].
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
13) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.80 Pain Relevance 0.25
In the present study we found that 24-hr DINP exposure significantly increased the production of the TH2-attracting chemokines TARC/CCL17 (Figure 3A) and MDC/CCL22 (Figure 3B) but not the TH1-polarizing cytokine IL-12p40 (data not shown), and increased the expression of CCR7, CXCR4 (Figure 3C,D), MHC class II, CD80, and CD86 (Figure 3E,F) in BMDCs.
Positive_regulation (increased) of Gene_expression (expression) of CD86 in CD86 associated with chemokine and cytokine
14) Confidence 0.32 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.25 Pain Relevance 0.24
, these DC's showed increased CD80 and CD86 expression and stimulated IL-4 production and priming of naïve CD4 T cells towards Th2 differentiation.
Positive_regulation (increased) of Gene_expression (expression) of CD86 in CD86
15) Confidence 0.31 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0
CD86 RNA expression after 24 hrs of LPS stimulation with 0, 1, 5, or 10 ?
Positive_regulation (after) of Gene_expression (expression) of CD86 in CD86
16) Confidence 0.31 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.09
Prostaglandin E2 from I. scapularis saliva showed a trend to increase CD86 expression of bone-marrow derived DC stimulated with LPS, while it inhibited IL-12 and TNF?
Positive_regulation (increase) of Gene_expression (expression) of CD86 in CD86
17) Confidence 0.31 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0
0.05) increased CD86 expression as compared to LPS alone, SGE alone or untreated cells.
Positive_regulation (increased) of Gene_expression (expression) of CD86 in CD86
18) Confidence 0.29 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.12
Higher concentrations of SGE were less effective at increasing CD86 RNA expression.
Positive_regulation (increasing) of Gene_expression (expression) of CD86 in CD86
19) Confidence 0.29 Published 2010 Journal Parasit Vectors Section Abstract Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.03
Rhipicephalus microplus salivary gland molecules induce differential CD86 expression in murine macrophages

Background

Positive_regulation (induce) of Gene_expression (expression) of CD86 in macrophages
20) Confidence 0.29 Published 2010 Journal Parasit Vectors Section Title Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.04

General Comments

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