INT135991

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 6.90
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 28
B cells 4
T cells 4
monocytes 2
Cd80 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 228 99.36 Very High Very High Very High
Inflammation 156 98.50 Very High Very High Very High
chemokine 62 97.66 Very High Very High Very High
transdermal 5 88.92 High High
Arthritis 41 82.12 Quite High
imagery 49 65.80 Quite High
Deep tissue 2 55.80 Quite High
Multiple sclerosis 6 53.60 Quite High
Spinal cord 6 52.20 Quite High
tolerance 14 50.00 Quite Low
Disease Link Frequency Relevance Heat
Fever 17 99.98 Very High Very High Very High
Cancer 372 99.58 Very High Very High Very High
Candida Infection 137 99.54 Very High Very High Very High
Multiple Sclerosis 12 99.32 Very High Very High Very High
INFLAMMATION 153 98.50 Very High Very High Very High
Diphtheria 3 96.40 Very High Very High Very High
Infection 267 94.96 High High
Influenza Virus Infection 5 90.40 High High
Respiratory Syncytial Virus 62 89.68 High High
Immunization 28 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CpG-ODN, a known potent DC stimulator, induced the highest level of IL-12p70 production while only moderately increasing IL-10 production, and significantly enhanced the expression of CD80 and CD86, indicating CpG-ODN induced immature DC towards a mature phenotype.
Positive_regulation (enhanced) of Gene_expression (expression) of CD80 in CD86
1) Confidence 0.54 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.49 Pain Relevance 0.04
Hyperthermia increases the expression of co-stimulatory molecules such as CD80 and CD86.
Positive_regulation (increases) of Gene_expression (expression) of CD80 in CD86 associated with fever
2) Confidence 0.50 Published 2006 Journal Vaccine Section Abstract Doc Link 16735086 Disease Relevance 1.10 Pain Relevance 0.18
Furthermore, both 55°C-HIFU- and 80°C-HIFU-treated tumor cells significantly enhanced surface expressions of CD80 and CD86 on co-cultured DCs.
Positive_regulation (enhanced) of Gene_expression (expressions) of CD80 in CD86 associated with cancer
3) Confidence 0.36 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.77 Pain Relevance 0.04
In cultures pretreated with vitamin C, the levels of both CD80 and CD86 after activation were similar to the control group.
Positive_regulation (activation) of Gene_expression (levels) of CD80 in CD86
4) Confidence 0.36 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
One important amplification loop is the stimulation of CD40 on DCs by CD40 ligand expressed on activated CD4 T cells, which upregulates CD80/CD86 expression [22].
Positive_regulation (upregulates) of Gene_expression (expression) of CD80 in T cells
5) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.18 Pain Relevance 0
It was found that LPS mediated a similar increase in the expression of CD40, CD80, CD86 and MHC II for both SPIO-labeled and unlabeled B cells (Fig. 1E).
Positive_regulation (increase) of Gene_expression (expression) of CD80 in B cells
6) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.06 Pain Relevance 0.15
These results was consistent with the report from Anne Krug that CpG could promote survival of PDCs, activate purified PDCs by a rapid increase of CD80, CD86 and CD40 expression but the increased degree of CD80 was much lower than that of CD86 [37].
Positive_regulation (increase) of Gene_expression (expression) of CD80 in CD86
7) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.29 Pain Relevance 0
As B cells are being activated, they up-regulate surface expression of co-stimulatory molecules such as CD80 and CD86.
Positive_regulation (regulate) of Gene_expression (expression) of CD80 in B cells
8) Confidence 0.33 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
As a result, although CSBG did not significantly enhance the total expression of surface markers (DEC205, CD80, and CD86) as an activation marker and accessory molecules on BMDCs, the rate of highly expressed molecules was significantly greater in the higher concentration of CSBG than the control.
Neg (not) Positive_regulation (enhance) of Gene_expression (expression) of CD80 in CD86 associated with candida infection
9) Confidence 0.30 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 0.99 Pain Relevance 0.06
Surface molecules such as CD80 can be transferred from APC to T cells by cell-cell contact [13].
Positive_regulation (transferred) of Gene_expression (transferred) of CD80 in T cells
10) Confidence 0.29 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.47 Pain Relevance 0
Silencing was specific in that CD 40 siRNA did not change gene expression of CD80 in DCs (Figure 1C).
Neg (not) Positive_regulation (change) of Gene_expression (expression) of CD80
11) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.24 Pain Relevance 0.07
Initial suboptimal stimulation of CD4+ T cells induces CD154 to engage CD40 on DCs, which then upregulates the expression of CD80 and CD86, facilitating further co-stimulation through CD28.
Positive_regulation (facilitating) of Gene_expression (expression) of CD80 in CD86
12) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.05 Pain Relevance 0
Exposure of NSPCs to an inflammatory environment triggers the expression of these costimulatory molecules like increased CD80 expression in the SVZ during the course of EAE [13].
Positive_regulation (increased) of Gene_expression (expression) of CD80 associated with multiple sclerosis and inflammation
13) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.55 Pain Relevance 0.26
dim cells, T cells were cocultured with Chinese hamster ovary (CHO) cells transfected with CD80 or CD86 (generously provided by Dr D.
Positive_regulation (transfected) of Gene_expression (transfected) of CD80 in CD86
14) Confidence 0.21 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.11 Pain Relevance 0.12
In the present study we found that 24-hr DINP exposure significantly increased the production of the TH2-attracting chemokines TARC/CCL17 (Figure 3A) and MDC/CCL22 (Figure 3B) but not the TH1-polarizing cytokine IL-12p40 (data not shown), and increased the expression of CCR7, CXCR4 (Figure 3C,D), MHC class II, CD80, and CD86 (Figure 3E,F) in BMDCs.
Positive_regulation (increased) of Gene_expression (expression) of CD80 in CD86 associated with chemokine and cytokine
15) Confidence 0.21 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.25 Pain Relevance 0.24
, these DC's showed increased CD80 and CD86 expression and stimulated IL-4 production and priming of naïve CD4 T cells towards Th2 differentiation.
Positive_regulation (increased) of Gene_expression (expression) of CD80 in CD86
16) Confidence 0.18 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0
Moreover, enhanced expression of CD80 and CD86, as well as MHC class I (but not MHC class II), is observed in vitro upon exposure of NSPCs to pro-inflammatory cytokines like IFN-?
Positive_regulation (enhanced) of Gene_expression (expression) of CD80 in CD86 associated with inflammation and cytokine
17) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.41 Pain Relevance 0.24
Moreover, enhanced expression of CD80 and CD86, as well as MHC class I (but not MHC class II), is observed in vitro upon exposure of NSPCs to pro-inflammatory cytokines like IFN-?
Positive_regulation (observed) of Gene_expression (expression) of CD80 in CD86 associated with inflammation and cytokine
18) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.41 Pain Relevance 0.25
Similar to leptin effect on monocytes,it may increase the survival of dendritic cells, and it may also increase the expression of surface molecules, such as CD1a, CD80, CD83, or CD86.
Spec (may) Positive_regulation (increase) of Gene_expression (expression) of CD80 in monocytes
19) Confidence 0.16 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.21 Pain Relevance 0.07
As demonstrated by flow cytometry analysis, Gal-4 significantly inhibited expression of the co-stimulatory molecules CD80 and CD86 expression on PBMC (Fig. 3A).
Positive_regulation (molecules) of Gene_expression (expression) of CD80 in CD86
20) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox