INT1360

Context Info Confidence 0.43 First Reported 1977 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 0.77 Pain Relevance 2.86

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)

Anatomy Link Frequency hypothalamus 2 fourth ventricle 2 Gnrhr (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 19 100.00 narcan 3 100.00 Morphine 2 100.00 agonist 4 99.36 antagonist 8 98.92 Opioid 4 97.52 depression 5 97.04 positron emission tomography 1 88.32 Neurotransmitter 3 87.44 midbrain 1 85.28

Disease Link Frequency Relevance Heat Depression 6 100.00 Neurosis 1 99.36 Sprains And Strains 6 75.00 Pressure And Volume Under Development 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Placement of radiofrequency lesions in the mediobasal hypothalamus or pretreatment with anti-GnRH serum completely abolished the ability of both morphine and naloxone to modulate the number of GnRH-R.

Negative_regulation (abolished) of Regulation (modulate) of GnRH-R in hypothalamus associated with narcan and morphine

1) Confidence 0.43 Published 1985 Journal Endocrinology Section Abstract Doc Link 2857637 Disease Relevance 0 Pain Relevance 0.98

Pretreatment with the alpha 2 adrenergic antagonists, yohimbine and 1-(2-pyrimidyl)piperazine, completely blocked clonidine's effect on growth hormone levels.

Negative_regulation (blocked) of Regulation (effect) of growth hormone associated with antagonist and clonidine

2) Confidence 0.42 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1356149 Disease Relevance 0.15 Pain Relevance 0.79

Several neuroendocrine studies with the clonidine-growth hormone stimulation test show endogenous depressive patients to have a reduced GH response as compared to neurotic depressives, schizophrenics and controls.

Negative_regulation (reduced) of Regulation (response) of clonidine-growth hormone associated with depression, neurosis and clonidine

3) Confidence 0.36 Published 1986 Journal Psychopathology Section Abstract Doc Link 3033728 Disease Relevance 0.36 Pain Relevance 0.27

Much of the evidence, though, has been indirect, such as an attenuated growth hormone response to the alpha2-adrenoceptor agonist clonidine.

Negative_regulation (attenuated) of Regulation (response) of growth hormone associated with agonist and clonidine

4) Confidence 0.36 Published 2001 Journal Biol. Psychiatry Section Abstract Doc Link 11239902 Disease Relevance 0.26 Pain Relevance 0.48

The effects on ACTH and growth hormone are abolished by administration of phenoxybenzamine into the third ventricle, whereas the effect on blood pressure is abolished by administration of phenoxybenzamine in the fourth ventricle without any effect on the ACTH and growth hormone responses.

Negative_regulation (abolished) of Regulation (effects) of growth hormone in fourth ventricle

5) Confidence 0.01 Published 1977 Journal Fed. Proc. Section Abstract Doc Link 191299 Disease Relevance 0 Pain Relevance 0.34

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