INT136012

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 2.76
Pain Relevance 9.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
amygdala 4
hippocampus 3
DA neurons 2
cortex 1
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 392 100.00 Very High Very High Very High
fluoxetine 110 100.00 Very High Very High Very High
bDMF 6 100.00 Very High Very High Very High
Hippocampus 270 99.68 Very High Very High Very High
Dopamine 115 99.40 Very High Very High Very High
amygdala 19 99.00 Very High Very High Very High
Dynorphin 6 98.42 Very High Very High Very High
B1 receptor 34 98.20 Very High Very High Very High
antagonist 34 97.72 Very High Very High Very High
depression 484 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 103 98.12 Very High Very High Very High
Depression 625 96.08 Very High Very High Very High
Neurodegenerative Disease 14 85.20 High High
Infection 5 74.88 Quite High
INFLAMMATION 15 69.12 Quite High
Injury 9 50.56 Quite High
Stress 150 19.72 Low Low
Hypothermia 3 17.28 Low Low
Shock 24 11.48 Low Low
Adhesions 6 6.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interesting results were noted when individual BDNF transcripts were examined after antidepressant treatment of corticosterone-implanted rats: the antidepressants were able to increase mRNA levels of only those BDNF transcripts that were affected when the respective antidepressant was given to healthy rats without corticosterone pellet implantation.
Regulation (affected) of Transcription (levels) of BDNF associated with antidepressant
1) Confidence 0.45 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.54 Pain Relevance 0.98
Of note, BDNF mRNA expression was not significantly altered by previous administration of the selective B1 receptor antagonist SSR240612.
Neg (not) Regulation (altered) of Transcription (expression) of BDNF associated with antagonist and b1 receptor
2) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.75 Pain Relevance 0.87
We observed higher BDNF mRNA levels in the fasting MTII injected mice than in the control fasting mice (figure 7A).
Regulation (injected) of Transcription (levels) of BDNF associated with bdmf
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.41
Another recent study by Altieri et al118 also showed no effect of long-term fluoxetine treatment on BDNF transcripts in the hippocampus.
Neg (no) Regulation (effect) of Transcription (transcripts) of BDNF in hippocampus associated with hippocampus and fluoxetine
4) Confidence 0.27 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.30 Pain Relevance 1.15
In another study, Dias et al102 examined the effects of long-term antidepressants on BDNF transcript levels in the rat hippocampus, amygdala, and cortex.
Spec (examined) Regulation (effects) of Transcription (levels) of BDNF in amygdala associated with antidepressant, hippocampus and amygdala
5) Confidence 0.27 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.27 Pain Relevance 1.26
Thus, it appears that antidepressants are effective in causing an increase in total BDNF expression in corticosterone-treated rats; however, the mechanisms for the down-regulation of BDNF transcripts by corticosterone and those that affect their upregulation by antidepressants are quite different.


Regulation (regulation) of Transcription (transcripts) of BDNF associated with antidepressant
6) Confidence 0.27 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.31 Pain Relevance 0.61
Combined treatment produced no effect on BDNF mRNA expression.
Neg (no) Regulation (effect) of Transcription (expression) of BDNF
7) Confidence 0.26 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16740621 Disease Relevance 0.05 Pain Relevance 0.66
As striatal dynorphin positive neurons form connections with nigral DA neurons, we investigated the effects of the mutation on nigral BDNF mRNA levels.
Spec (investigated) Regulation (effects) of Transcription (levels) of BDNF in DA neurons associated with dopamine and dynorphin
8) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.75
In another study, Dias et al102 examined the effects of long-term antidepressants on BDNF transcript levels in the rat hippocampus, amygdala, and cortex.
Spec (examined) Regulation (effects) of in cortex Transcription (levels) of BDNF in amygdala associated with antidepressant, hippocampus and amygdala
9) Confidence 0.09 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.27 Pain Relevance 1.26
In another study, Dias et al102 examined the effects of long-term antidepressants on BDNF transcript levels in the rat hippocampus, amygdala, and cortex.
Spec (examined) Regulation (effects) of in hippocampus Transcription (levels) of BDNF in amygdala associated with antidepressant, hippocampus and amygdala
10) Confidence 0.09 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.27 Pain Relevance 1.26

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