INT13602

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 1986
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 15
Disease Relevance 10.53
Pain Relevance 14.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NCF4) cytoplasm (NCF4)
Anatomy Link Frequency
face 5
Nucleus 2
medulla 1
neurons 1
lamina 1
NCF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Raphe magnus 91 99.84 Very High Very High Very High
Opioid 12 99.60 Very High Very High Very High
Migraine 900 99.58 Very High Very High Very High
imagery 132 99.44 Very High Very High Very High
Pain 246 99.28 Very High Very High Very High
positron emission tomography 12 99.24 Very High Very High Very High
medulla 290 99.08 Very High Very High Very High
analgesia 12 98.96 Very High Very High Very High
antagonist 3 97.76 Very High Very High Very High
central sensitization 60 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 936 99.58 Very High Very High Very High
Cognitive Disorder 24 99.50 Very High Very High Very High
Pain 281 99.28 Very High Very High Very High
Hyperalgesia 12 96.56 Very High Very High Very High
Nociception 108 96.48 Very High Very High Very High
Congenital Anomalies 60 94.12 High High
Neuropathic Pain 48 88.96 High High
Urological Neuroanatomy 84 84.32 Quite High
Disease 12 35.28 Quite Low
Migraine Disorders 24 28.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NCF is also activated during the expectation of pain, indicating that awareness of impending pain can trigger a preparatory modulatory process in NCF [15].
Positive_regulation (activated) of NCF associated with pain
1) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 0.80 Pain Relevance 1.35
In the healthy group, the NCF activation we observed with both 41°C and noxious heat could be conceivably driven by thermal and nociceptive inputs from lamina I in the trigeminal nucleus (face)/dorsal horn (hand) [26], as well as wide dynamic range neurons in deeper lamina such as IV and V [29].
Positive_regulation (activation) of NCF in lamina associated with nociception, dorsal horn and wide dynamic range
2) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 0.65 Pain Relevance 0.78
Nucleus cuneiformis (NCF), a component of brainstem pain modulatory circuits, appears to be hypofunctional in migraineurs. 3 out of the 4 thermal stimulus conditions showed significantly greater NCF activation in control subjects than the migraine patients.


Positive_regulation (activation) of NCF in Nucleus associated with pain, medulla and migraine
3) Confidence 0.68 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2582961 Disease Relevance 0.86 Pain Relevance 1.23
In our migraine patients, we found that NCF activation was disrupted not only for stimuli applied to the face, but also the hand.
Positive_regulation (activation) of NCF in face associated with migraine
4) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 1.25 Pain Relevance 1.16
The absence of a difference between migraine and control subject NCF activation for noxious stimuli to the face in migraine patients (Fig. 1) is unexpected, in light of the impaired descending modulation model.
Positive_regulation (activation) of NCF in face associated with migraine
5) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 0.90 Pain Relevance 0.89
Human imaging studies have reported that activations in NCF and the rostroventral medulla are correlated during repeated noxious stimulation [14], and also that NCF may activate during punctate mechanical hyperalgesia, suggesting that it is involved in a alterations in descending pain modulation [16].
Positive_regulation (activations) of NCF in medulla associated with pain, medulla, hyperalgesia and imagery
6) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 0.75 Pain Relevance 1.38
Activation in NCF was observed bilaterally for the face stimulation site, and was predominantly contralateral for the hand (Table 1).
Positive_regulation (Activation) of NCF in face
7) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 0.79 Pain Relevance 0.90
The noxious heat stimulus (Thr+1°C) applied to the face and hand resulted in significant activation of this same NCF region in both migraine and control subjects.
Positive_regulation (activation) of NCF in face associated with migraine
8) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 0.96 Pain Relevance 1.00
In animal studies, electrical stimulation of NCF produces opioid-mediated analgesia through excitatory cholinergic projections to the nucleus raphe magnus (NRM) [9], [11].
Positive_regulation (stimulation) of NCF in nucleus associated with raphe magnus, opioid and analgesia
9) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 0.49 Pain Relevance 1.14
At this higher intensity level, the NCF activation in the control subjects was significantly greater than in migraine subjects for stimuli applied to the hand, though not the face (Fig. 1; Table 1).
Positive_regulation (activation) of NCF in face associated with migraine
10) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 1.00 Pain Relevance 1.01
In the lightly anesthetized rat, low-intensity electrical stimulation of NCF excited 53% of NRM neurons at short latencies (mean onset, 3.9 ms), while 20% of NRM neurons were inhibited.
Positive_regulation (stimulation) of NCF in neurons associated with raphe magnus
11) Confidence 0.40 Published 1991 Journal Brain Res. Section Abstract Doc Link 1674895 Disease Relevance 0.15 Pain Relevance 0.72
Pharmacological stimulation of NCF with glutamic acid induced mixed effects, as 34% of NRM cells were excited while 37% were inhibited.
Positive_regulation (stimulation) of NCF associated with raphe magnus
12) Confidence 0.40 Published 1991 Journal Brain Res. Section Abstract Doc Link 1674895 Disease Relevance 0.07 Pain Relevance 0.58
NCF can be triggered during the anticipation of pain, before a stimulus is even applied [15], [37]: this suggests that the perception of physical stimuli is not necessary for NCF activation, and that cognitive processes may influence NCF activation in healthy subjects perhaps more effectively than in migraine patients.
Positive_regulation (triggered) of NCF associated with pain, cognitive disorder and migraine
13) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 0.91 Pain Relevance 0.92
NCF can be triggered during the anticipation of pain, before a stimulus is even applied [15], [37]: this suggests that the perception of physical stimuli is not necessary for NCF activation, and that cognitive processes may influence NCF activation in healthy subjects perhaps more effectively than in migraine patients.
Positive_regulation (activation) of NCF associated with pain, cognitive disorder and migraine
14) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582961 Disease Relevance 0.87 Pain Relevance 0.81
Therefore, we investigated the effect of NCF stimulation on NRM unit activity and explored the possible role of acetylcholine (ACh) in this interaction.
Spec (investigated) Positive_regulation (stimulation) of NCF associated with raphe magnus
15) Confidence 0.29 Published 1986 Journal Brain Res. Section Abstract Doc Link 3697735 Disease Relevance 0.09 Pain Relevance 0.43

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox