INT136021

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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.63
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPO) extracellular space (EPO) aging (EPO)
extracellular region (EPO)
Anatomy Link Frequency
red blood cell 2
kidney 2
EPO (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 1 83.52 Quite High
Endogenous opioid 1 67.08 Quite High
Neuropeptide 1 63.04 Quite High
dexamethasone 14 43.68 Quite Low
ischemia 2 10.16 Low Low
headache 10 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 42 99.74 Very High Very High Very High
Cardiovascular Disease 3 77.20 Quite High
Hypocapnia 8 76.48 Quite High
Altitude Sickness 130 75.68 Quite High
Increased Venous Pressure Under Development 14 74.92 Quite High
Pressure And Volume Under Development 44 72.08 Quite High
Syndrome 10 69.32 Quite High
Heart Rate Under Development 24 68.88 Quite High
Diuresis 8 63.68 Quite High
Acid Base Imbalance 4 45.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus there is an increase in pulmonary ventilation, increase in diffusing capacity in the lung, an increase in the cardiac output and increase in the red blood cell count due to an increase in erythropoietin secretion by the kidney, all of which enhance oxygen delivery to the cells.
Positive_regulation (increase) of Localization (secretion) of erythropoietin in red blood cell
1) Confidence 0.23 Published 2010 Journal Indian Journal of Occupational and Environmental Medicine Section Abstract Doc Link PMC2923424 Disease Relevance 0.62 Pain Relevance 0
Hypoxia is the main stimulus for the release of the hormone erythropoietin from the kidney.
Positive_regulation (stimulus) of Localization (release) of erythropoietin in kidney associated with hypoxia
2) Confidence 0.17 Published 2010 Journal Indian Journal of Occupational and Environmental Medicine Section Body Doc Link PMC2923424 Disease Relevance 0.79 Pain Relevance 0
Via adenovirus gene delivery, the POMC-transduced EA.hy926 cells released significantly elevated ACTH and beta-EP levels (P < 0.001).
Positive_regulation (elevated) of Localization (released) of EP
3) Confidence 0.15 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16740999 Disease Relevance 0.22 Pain Relevance 0.14

General Comments

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