INT136034

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.39
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) extracellular space (Edn1) extracellular region (Edn1)
plasma membrane (Trpv1) lipid metabolic process (Trpv1) cell-cell signaling (Edn1)
Anatomy Link Frequency
sensory neurons 1
neurons 1
Edn1 (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 45 95.08 Very High Very High Very High
Inflammation 6 89.84 High High
Pain 15 88.56 High High
qutenza 85 88.36 High High
nociceptor 13 77.72 Quite High
bradykinin 20 76.96 Quite High
antagonist 9 48.80 Quite Low
agonist 10 5.00 Very Low Very Low Very Low
algogenic 8 5.00 Very Low Very Low Very Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 47 95.08 Very High Very High Very High
INFLAMMATION 6 89.84 High High
Pain 10 54.80 Quite High
Nociception 14 5.00 Very Low Very Low Very Low
Hyperalgesia 10 5.00 Very Low Very Low Very Low
Neuropathic Pain 8 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Reprotox - General 1 2 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To provide evidence that ET-1 can modulate TRPV1 activity via the ET(A) receptor, we used HEK 293 cells transiently co-expressing a fusion protein of TRPV1 and the yellow fluorescent protein (TRPV1-YFP) and the ET(A) receptor.
ET-1 Regulation (modulate) of TRPV1
1) Confidence 0.66 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16741069 Disease Relevance 0.29 Pain Relevance 0.75
Owing to the small fraction of neurons that responded to ET-1, the regulation of TRPV1 by ET-1 was analysed in HEK293 cells transiently co-transfected with plasmids encoding TRPV1-YFP and the ETAR or ETBR.
ET-1 Spec (analysed) Regulation (regulation) of TRPV1 in neurons
2) Confidence 0.52 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.57
We also show that ET-1 potently modulates the functional activity of TRPV1 in a subpopulation of sensory neurons and in HEK293 cells co-expressing the ETAR and TRPV1.
ET-1 Regulation (modulates) of TRPV1 in sensory neurons
3) Confidence 0.23 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0.10 Pain Relevance 0.26

General Comments

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