INT136052

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
paw 2
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1 96.80 Very High Very High Very High
guanethidine 1 96.08 Very High Very High Very High
nociceptor 2 86.12 High High
Dopamine 5 62.56 Quite High
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 9 99.52 Very High Very High Very High
INFLAMMATION 1 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injection of 5-hydroxytryptamine into the s.c. tissue of the hind paw of rats produced nociceptive flinch behavior and inflammatory cell migration, that were significantly reduced by the nonspecific selectin inhibitor fucoidan. 5-Hydroxytryptamine-induced nociception was also significantly reduced by local blockade of the 5-HT3 receptor by tropisetron, by the cyclooxygenase inhibitor indomethacin and by local blockade of the beta1-adrenergic receptor or of the D1 receptor by atenolol or SCH 23390, respectively.
Negative_regulation (reduced) of Negative_regulation (blockade) of D1 receptor in paw associated with nociception and inflammation
1) Confidence 0.13 Published 2006 Journal Neuroscience Section Abstract Doc Link 16750893 Disease Relevance 0.66 Pain Relevance 0.27

General Comments

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