INT13606

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Context Info
Confidence 0.40
First Reported 1987
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 1.21
Pain Relevance 10.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
brain 4
endothelium 4
paw 2
caudate putamen 2
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 25 100.00 Very High Very High Very High
opioid receptor 13 100.00 Very High Very High Very High
Dopamine 4 100.00 Very High Very High Very High
narcan 10 99.84 Very High Very High Very High
Opioid 11 99.82 Very High Very High Very High
tolerance 13 99.62 Very High Very High Very High
Morphine 31 99.54 Very High Very High Very High
Immobilon 2 99.54 Very High Very High Very High
Antinociceptive 10 99.42 Very High Very High Very High
diclofenac 8 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 5 99.20 Very High Very High Very High
Aids-related Complex 1 87.36 High High
Urological Neuroanatomy 1 85.44 High High
Movement Disorders 2 85.20 High High
Ganglion Cysts 2 79.60 Quite High
Hyperalgesia 4 78.24 Quite High
Hyperkinesis 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is substantiated by inhibition of adaptive relaxation by NG-monomethyl-L-arginine or N omega-nitro-L-arginine methyl ester, both inhibitors of NO synthesis, and by methylene blue, an inhibitor of soluble guanylate cyclase.
Negative_regulation (inhibition) of Negative_regulation (inhibitor) of guanylate cyclase
1) Confidence 0.40 Published 1991 Journal Nature Section Abstract Doc Link 1675430 Disease Relevance 0.17 Pain Relevance 0.18
Removal of endothelium, inhibition of guanylate cyclase, inhibition of NO biosynthesis and inactivation of NO significantly reduced these relaxations.
Negative_regulation (reduced) of Negative_regulation (inhibition) of guanylate cyclase in endothelium
2) Confidence 0.32 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7705433 Disease Relevance 0 Pain Relevance 0.24
Chronic morphine treatment also resulted in a reduction of dopamine D2 receptor-mediated inhibition of A2a receptor-stimulated adenylyl cyclase.
Negative_regulation (reduction) of Negative_regulation (inhibition) of cyclase associated with dopamine and morphine
3) Confidence 0.16 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353370 Disease Relevance 0 Pain Relevance 0.91
Morphine treatment of rats (60-70 mg/kg/day, 7 days) reduced delta opioid receptor-mediated inhibition of adenylyl cyclase activity in caudate putamen without any change in regulation by mu receptors.
Negative_regulation (reduced) of Negative_regulation (inhibition) of cyclase in caudate putamen associated with opioid receptor and morphine
4) Confidence 0.16 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353370 Disease Relevance 0 Pain Relevance 0.60
Combined inhibition of guanylate cyclase and norepinephrine disposition increased the contractions and abolished the difference between the responses of rings with and without endothelium.
Negative_regulation (abolished) of Negative_regulation (inhibition) of guanylate cyclase in endothelium
5) Confidence 0.12 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3499086 Disease Relevance 0 Pain Relevance 0.12
The results also show that following chronic exposure of cultured cells to etorphine or U50488, there is a loss of kappa agonist inhibition of the cyclase.
Negative_regulation (loss) of Negative_regulation (inhibition) of cyclase associated with agonist and immobilon
6) Confidence 0.11 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2536070 Disease Relevance 0.07 Pain Relevance 1.17
Seven days of chronic sufentanil treatment developed antinociceptive tolerance associated with a reduction in mu-agonist-induced [35S]GTP gamma S binding, mu-agonist-induced adenylyl cyclase inhibition, and co-precipitation of G alpha o, G alpha i2 G alpha z and G alpha q11 subunits with mu-opioid receptors.
Negative_regulation (reduction) of Negative_regulation (inhibition) of cyclase associated with mu opioid receptor, agonist, tolerance and antinociceptive
7) Confidence 0.10 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18384820 Disease Relevance 0.17 Pain Relevance 1.08
Both the overshoot and acute opioid-induced cyclase inhibition are blocked by naloxone and are pertussis toxin-sensitive, indicating that both phenomena are mediated by the mu-receptor and Gi/G(o) proteins.
Negative_regulation (blocked) of Negative_regulation (inhibition) of cyclase associated with bordatella infection, narcan and opioid
8) Confidence 0.07 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 8530363 Disease Relevance 0.10 Pain Relevance 1.15
In rats treated with morphine alone, the inhibitory effect of DAMGO on forskolin-stimulated adenylyl cyclase activity was significantly reduced in a brain-region-selective manner.
Negative_regulation (reduced) of Negative_regulation (effect) of cyclase in brain associated with morphine
9) Confidence 0.05 Published 2007 Journal Pharmacology Section Abstract Doc Link 17356311 Disease Relevance 0 Pain Relevance 0.99
The inhibitory effects of GTP on basal adenylate cyclase activity, between 10(-6) and 10(-4) M, were reduced.
Negative_regulation (reduced) of Negative_regulation (effects) of cyclase
10) Confidence 0.05 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2833270 Disease Relevance 0 Pain Relevance 0.56
Pertussis toxin treatment in vitro significantly reduced DADLE-inhibition of adenylate cyclase in all brain areas, indicating that this opiate response is mediated by a pertussis toxin-sensitive G-protein (i.e., Gi and/or Go).
Negative_regulation (reduced) of Negative_regulation (inhibition) of cyclase in brain associated with bordatella infection and opiate
11) Confidence 0.05 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2843624 Disease Relevance 0.28 Pain Relevance 1.34
The peripheral antinociceptive effect induced by diclofenac was antagonized by NG-Nitro L-arginine (NOarg, 50 microg/paw), a NO synthase inhibitor and methylene blue (MB, 500 microg/paw), a guanylate cyclase inhibitor, and this antagonism was reversed by diazoxide (300 microg/paw), an ATP-sensitive K+ channel opener.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of cyclase in paw associated with diclofenac and antinociceptive
12) Confidence 0.05 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010267 Disease Relevance 0.27 Pain Relevance 0.90
In agreement with a lack of desensitization of mu-opioid receptors, 3 hr of continuous exposure of the cloned mu receptor to endomorphin-1 did not diminish the subsequent ability of the agonist to inhibit adenylate cyclase activity in cells expressing the cloned mu-opioid receptor.
Neg (not) Negative_regulation (diminish) of Negative_regulation (inhibit) of cyclase associated with agonist, mu opioid receptor and opioid receptor
13) Confidence 0.03 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404430 Disease Relevance 0.15 Pain Relevance 0.75

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