INT136074

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Context Info
Confidence 0.23
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.60
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ELOVL1) endoplasmic reticulum (ELOVL1)
Anatomy Link Frequency
proximal 1
ELOVL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 16 99.64 Very High Very High Very High
Cholecystokinin 2 74.56 Quite High
fibrosis 38 72.40 Quite High
nud 70 70.24 Quite High
Pain 18 50.00 Quite Low
ischemia 36 46.56 Quite Low
visual analogue scale 18 5.00 Very Low Very Low Very Low
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Sclerosis 447 100.00 Very High Very High Very High
Rare Diseases 2 100.00 Very High Very High Very High
Enteropathy 2 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 17 96.96 Very High Very High Very High
Gastric Motility Disorder 16 92.64 High High
Gallstones 6 79.20 Quite High
Apoptosis 2 74.36 Quite High
Fibrosis 28 72.40 Quite High
Hypertrophy 1 71.40 Quite High
Dyspepsia 70 70.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SSc is a rare disease that is estimated to affect between 2 and 10 people/million each year in the Western world [5].
Regulation (affect) of SSc associated with rare diseases and systemic sclerosis
1) Confidence 0.23 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.40 Pain Relevance 0
Evidence has shown that both proximal and distal arteries are affected in SSc-related vasculopathy resulting in digital ischemic loss.
Regulation (affected) of SSc in proximal associated with systemic sclerosis
2) Confidence 0.13 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2943156 Disease Relevance 1.02 Pain Relevance 0.04
CONCLUSION: The QoL of patients with SSc is strongly influenced by the type of SSc, the burden of clinical manifestations, the functional disability and by the pain, whatever its cause.
Regulation (influenced) of SSc
3) Confidence 0.08 Published 2006 Journal Rheumatology (Oxford) Section Body Doc Link 16754629 Disease Relevance 0.11 Pain Relevance 0
Interestingly, it has been recently suggested that a long term treatment with octreotide LAR may be effective for treatment of small intestinal disease in SSc patients [17].
Spec (may) Regulation (effective) of SSc associated with enteropathy and systemic sclerosis
4) Confidence 0.04 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2276219 Disease Relevance 0.99 Pain Relevance 0.06
Although the study concluded that there was little evidence that methotrexate is significantly effective in the treatment of early diffuse SSc, there were some significant differences between patients given methotrexate and those who received placebo.
Regulation (effective) of SSc associated with systemic sclerosis and methotrexate
5) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2072887 Disease Relevance 0.18 Pain Relevance 0.35
However, at variance with the gallbladder emptying, the gallbladder refilling has been shown to be altered in both SSc patients and dyspeptic controls.
Regulation (altered) of SSc associated with systemic sclerosis
6) Confidence 0.02 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2276219 Disease Relevance 0.89 Pain Relevance 0.04

General Comments

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