INT13608

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.97
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ggh) extracellular space (Ggh) extracellular region (Ggh)
lysosome (Ggh)
Anatomy Link Frequency
hearts 2
Ggh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 7 100.00 Very High Very High Very High
Somatostatin 14 99.82 Very High Very High Very High
antagonist 12 99.80 Very High Very High Very High
anesthesia 5 98.96 Very High Very High Very High
Bioavailability 2 97.24 Very High Very High Very High
dexamethasone 10 95.76 Very High Very High Very High
Enkephalin 2 91.28 High High
ischemia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Insulin Resistance 2 99.80 Very High Very High Very High
Obesity 28 99.48 Very High Very High Very High
Hyperinsulinism 2 99.48 Very High Very High Very High
Hyperlipidemia 2 98.76 Very High Very High Very High
Impaired Glucose Tolerance 2 98.00 Very High Very High Very High
Cv Unclassified Under Development 4 94.40 High High
Sprains And Strains 2 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, as decreased GH secretion and insulin resistance are associated with increased cardiovascular risk, we also tested the capacity of hexarelin to prevent postischemic ventricular dysfunction in hearts of male obese Zucker rats.
Negative_regulation (decreased) of Localization (secretion) of GH in hearts associated with obesity, cv unclassified under development and insulin resistance
1) Confidence 0.45 Published 2000 Journal J. Endocrinol. Section Abstract Doc Link 10974647 Disease Relevance 1.13 Pain Relevance 0.09
Genetically obese male Zucker rats have an impaired secretion of GH, coupled to hyperinsulinemia, hyperlipidemia and glucose intolerance.
Negative_regulation (impaired) of Localization (secretion) of GH associated with obesity, hyperinsulinism, hyperlipidemia and impaired glucose tolerance
2) Confidence 0.45 Published 2000 Journal J. Endocrinol. Section Abstract Doc Link 10974647 Disease Relevance 0.84 Pain Relevance 0.09
Orchidectomy on day 83 reduced this GHRH-induced GH secretion on day 90.
Negative_regulation (reduced) of Localization (secretion) of GH
3) Confidence 0.25 Published 1990 Journal Acta Endocrinol. Section Abstract Doc Link 2109443 Disease Relevance 0 Pain Relevance 0.08
BIM-23454 and BIM-23627, given iv, were able to counteract the SS-induced inhibition of GH secretion occurring after urethane anesthesia in a dose-dependent manner.
Negative_regulation (inhibition) of Localization (secretion) of GH associated with anesthesia and somatostatin
4) Confidence 0.20 Published 2002 Journal Endocrinology Section Abstract Doc Link 11897676 Disease Relevance 0 Pain Relevance 0.72
The SS antagonists showed a reduced GH-releasing effect when administered sc or ip, likely attributable to decreased bioavailability, as compared with the iv route.
Negative_regulation (reduced) of Localization (releasing) of GH associated with antagonist, somatostatin and bioavailability
5) Confidence 0.14 Published 2002 Journal Endocrinology Section Abstract Doc Link 11897676 Disease Relevance 0 Pain Relevance 0.83
When administered to ovariectomized rats injected earlier with morphine sulfate, Tyr-MIF-1 (0.2 and 2.0 mg/kg) reduced (p less than 0.05) the effect of morphine (5 mg/kg) on GH secretion and tended (p = 0.061) to partially inhibit the effect of morphine (10 mg/kg) on prolactin secretion at a dose of 2.0 mg/kg.
Negative_regulation (reduced) of Localization (secretion) of GH associated with morphine
6) Confidence 0.14 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1675454 Disease Relevance 0 Pain Relevance 0.62

General Comments

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