INT136093

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Context Info
Confidence 0.14
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.39
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FBN1) extracellular region (FBN1) proteinaceous extracellular matrix (FBN1)
Anatomy Link Frequency
capsule 2
lymph node 1
FBN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 4 99.80 Very High Very High Very High
Neuropeptide 238 97.80 Very High Very High Very High
diclofenac 68 97.28 Very High Very High Very High
metalloproteinase 12 96.56 Very High Very High Very High
COX2 108 96.44 Very High Very High Very High
Infliximab 80 95.08 Very High Very High Very High
fibrosis 80 87.84 High High
Inflammation 212 80.72 Quite High
cytokine 168 76.56 Quite High
Enkephalin 54 29.12 Quite Low
Disease Link Frequency Relevance Heat
Cirrhosis 200 100.00 Very High Very High Very High
Syndrome 4 99.92 Very High Very High Very High
Low Back Pain 4 99.80 Very High Very High Very High
Apoptosis 220 99.68 Very High Very High Very High
Fibrosis 160 98.88 Very High Very High Very High
Cancer 58 98.68 Very High Very High Very High
Wound Healing 60 98.36 Very High Very High Very High
Contracture 40 95.76 Very High Very High Very High
Injury 216 94.44 High High
Metastasis 13 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A change of fibrillin-1 due to mutation of the FBN1 gene (MFS) or a cell-mediated autoimmune response in AS could account for a common pathology.
Regulation (change) of FBN1 gene associated with spinal inflammation and syndrome
1) Confidence 0.14 Published 2006 Journal J. Rheumatol. Section Abstract Doc Link 16755670 Disease Relevance 0.74 Pain Relevance 0.37
Therefore, the high sensitivity of the mass spectrometry approach is advantageous for identifying neuropeptides.
Regulation (sensitivity) of mass associated with neuropeptide
2) Confidence 0.02 Published 2010 Journal AAPS J Section Body Doc Link PMC2976990 Disease Relevance 0 Pain Relevance 0.65
As shown in Table 3, tumor size, age categories and PAI-1 mRNA expression are of prognostic value for MFS while lymph node status, histological type, histological grade and uPA expression did not add significant independent prognostic information.
Regulation (value) of MFS in lymph node associated with cancer
3) Confidence 0.01 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.81 Pain Relevance 0
To therapeutically counteract an excessive ECM synthesis and contraction, it is most important to understand the molecular pathways that regulate the activation and function of MFs.
Regulation (regulate) of MFs
4) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.31 Pain Relevance 0.23
specifically modulates the function of MFs through regulation of prostaglandin E2 synthesis and therefore may play a crucial role in the pathogenesis of joint capsule contractures.



Regulation (modulates) of MFs in capsule associated with contracture
5) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875629 Disease Relevance 0.32 Pain Relevance 0.42
specifically modulates the function of MFs through regulation of prostaglandin E2 synthesis and therefore may play a crucial role in the pathogenesis of joint capsule contractures.



Regulation (regulation) of MFs in capsule associated with contracture
6) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875629 Disease Relevance 0.32 Pain Relevance 0.41
had a high proliferative effect on MFs at low concentrations already, it functionally inhibited the contraction of the ECM and downregulated the gene expression of ?
Regulation (effect) of MFs
7) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.10 Pain Relevance 0.19
In this scenario, the sensitivity of HSCs and HSC/MFs to pro-apoptotic stimuli has been investigated to gain basic knowledge for a putative cell targeted antifibrotic therapy [79-82,91,94,95,244].
Spec (investigated) Regulation (sensitivity) of MFs associated with cirrhosis and apoptosis
8) Confidence 0.00 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.19 Pain Relevance 0.13
This differs from what was suggested for ROS [75,77,80,81] and is likely to occur because quiescent HSCs can remove H2O2 less efficiently than fully activated cells [310,312], whereas HSC/MFs are more sensitive to HNE because they lack isoforms of GSH-S-transferase and aldehyde dehydrogenase able to remove or inactivate HNE [288,334].
Regulation (sensitive) of MFs associated with cirrhosis
9) Confidence 0.00 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.19 Pain Relevance 0
The ACA effect on HSC/MFs was biphasic, with an early phase being mediated by ACA and a late effect due to ACA-induced up-regulation of TGF?
Regulation (effect) of MFs
10) Confidence 0.00 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0 Pain Relevance 0.08
With regard to the pro-fibrogenic mechanism, HNE has been shown in human HSC/MFs to elicit transient activation of JNK isoforms and their nuclear translocation as well as to lead to up-regulation of c-Jun and increased AP-1 binding to DNA [288]; a very similar JNK/AP-1-dependent pattern, inducing up-regulation of collagen type I, has been shown to operate in rat HSC/MFs exposed to UV irradiation [309].
Regulation (operate) of MFs
11) Confidence 0.00 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.41 Pain Relevance 0.04

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