INT1361

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 118
Total Number 121
Disease Relevance 57.77
Pain Relevance 35.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
pituitary 12
plasma 10
thyroid 3
brain 2
blood 2
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Fibrositis 344 100.00 Very High Very High Very High
Clonidine 85 100.00 Very High Very High Very High
agonist 36 100.00 Very High Very High Very High
Neuropeptide 9 100.00 Very High Very High Very High
Nicotine 21 99.98 Very High Very High Very High
withdrawal 17 99.92 Very High Very High Very High
Sicca syndrome 1 99.88 Very High Very High Very High
Morphine 33 99.62 Very High Very High Very High
tolerance 10 99.62 Very High Very High Very High
monoamine 6 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Growth Hormone Deficiency 136 100.00 Very High Very High Very High
Eating Disorder 10 99.96 Very High Very High Very High
Sjoegrens Syndrome 1 99.88 Very High Very High Very High
Syndrome 300 99.84 Very High Very High Very High
Burns 10 99.84 Very High Very High Very High
Stress 248 99.82 Very High Very High Very High
Congenital Anomalies 83 99.80 Very High Very High Very High
Precocious Puberty 28 99.80 Very High Very High Very High
Empty Sella Syndrome 1 99.64 Very High Very High Very High
Aging 3 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of the dopaminergic agonists bromocriptine and L-dopa or the alpha-adrenergic receptor blocker phenoxybenzamine elevated GnRH-R acutely from average basal values of 240 +/- 22 and 254 +/- 21 fmol/mg protein to maximal values of 374 +/- 49, 441 +/- 67 and 461 +/- 75 fmol/mg, respectively, whereas the alpha-adrenergic agonist clonidine transiently decreased GnRH-R to 186 +/- 19 fmol/mg.
Negative_regulation (decreased) of GnRH-R associated with agonist and clonidine
1) Confidence 0.58 Published 1985 Journal Endocrinology Section Abstract Doc Link 2857637 Disease Relevance 0 Pain Relevance 0.98
Intravenous injections of nicotine decrease the pulsatile secretion of LH by inhibiting the gonadotropin-releasing hormone (GnRH) pulse generator activity in female rats.
Negative_regulation (inhibiting) of gonadotropin-releasing hormone associated with nicotine and narcan
2) Confidence 0.57 Published 1999 Journal Psychoneuroendocrinology Section Title Doc Link 10341367 Disease Relevance 0 Pain Relevance 0.61
In the present study, after desipramine (DMI) (75 mg i.m.), endogenous depressives show a significantly reduced growth hormone (HGH) response as compared to neurotic depressive patients and to controls.
Negative_regulation (reduced) of growth hormone associated with desipramine, depression and neurosis
3) Confidence 0.57 Published 1981 Journal Acta Psychiatr Scand Suppl Section Abstract Doc Link 6939310 Disease Relevance 0.63 Pain Relevance 0.35
The stress-induced inhibition of growth hormone was observed in Long Evans rats only, whereas the morphine stimulated plasma growth hormone increase was observed in animals of both strains.
Negative_regulation (inhibition) of growth hormone in plasma associated with stress, sprains and strains and morphine
4) Confidence 0.56 Published 1984 Journal Endocrinol. Exp. Section Abstract Doc Link 6335081 Disease Relevance 0.79 Pain Relevance 0.49
Growth hormone was suppressed in each subject demonstrating a biologically active infusion of somatostatin.
Negative_regulation (suppressed) of Growth hormone associated with somatostatin
5) Confidence 0.56 Published 2003 Journal Pain Section Abstract Doc Link 12670664 Disease Relevance 1.45 Pain Relevance 1.86
Postoperative hormonal suppression with either a gonadotropin-receptor hormone analogue or progestin (including the levonorgestrel intrauterine system) may be helpful in reducing pain and increasing time to recurrence of symptoms.
Negative_regulation (suppression) of gonadotropin-receptor hormone
6) Confidence 0.56 Published 2009 Journal Journal of minimally invasive gynecology Section Body Doc Link 19423059 Disease Relevance 0 Pain Relevance 0
A single dose of oral clonidine hydrochloride approximating 100 micrograms/sq m, followed by one blood sample after 60 minutes seems to be an effective and safe screening test for growth hormone deficiency in short children.
Negative_regulation (deficiency) of growth hormone in blood associated with growth hormone deficiency and clonidine
7) Confidence 0.55 Published 1985 Journal Am. J. Dis. Child. Section Abstract Doc Link 3969992 Disease Relevance 0.10 Pain Relevance 0.24
Pre-operatively, growth hormone deficiency was the most commonly encountered pituitary hormonal deficiency; however postoperatively, most children had diabetes insipidus.
Negative_regulation (deficiency) of growth hormone in pituitary associated with diabetes insipidus and growth hormone deficiency
8) Confidence 0.55 Published 2001 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 11515727 Disease Relevance 1.07 Pain Relevance 0.10
Plasma immunoreactive levels of SMS 201-995 related inversely to growth hormone concentration: A reproducible threshold for growth hormone inhibition in five of the patients, ranging from 70 to 1200 pg/mL, was maintained for 6 to 8 hours after the injections.
Negative_regulation (inhibition) of growth hormone in Plasma
9) Confidence 0.55 Published 1986 Journal Ann. Intern. Med. Section Abstract Doc Link 2877605 Disease Relevance 0.31 Pain Relevance 0.20
The analgesic effects of octreotide were neither related to significant inhibition of growth hormone nor influenced by naloxone.
Negative_regulation (inhibition) of growth hormone associated with analgesic and narcan
10) Confidence 0.55 Published 1991 Journal Pain Section Abstract Doc Link 1664509 Disease Relevance 0.70 Pain Relevance 0.84
The possible role of SRIF release in the mechanism of growth hormone inhibition following nociceptive stress is discussed.
Negative_regulation (inhibition) of growth hormone associated with stress, nociception and somatostatin
11) Confidence 0.54 Published 1984 Journal Neurosci. Lett. Section Abstract Doc Link 6149508 Disease Relevance 0.59 Pain Relevance 0.25
This demonstrated a remarkably selective reduction in the plasma growth hormone concentration with preservation of other pituitary function excluding mild diabetes insipidus.
Negative_regulation (reduction) of plasma growth hormone in pituitary associated with diabetes insipidus
12) Confidence 0.49 Published 1975 Journal Aust N Z J Med Section Abstract Doc Link 1058679 Disease Relevance 0.66 Pain Relevance 0.07
A blunted response was defined as a failure of growth hormone levels to rise at least 5 mU/l above baseline.
Negative_regulation (failure) of growth hormone
13) Confidence 0.47 Published 1990 Journal J Psychosom Res Section Abstract Doc Link 2172531 Disease Relevance 0.54 Pain Relevance 0.57
Serum growth hormone levels increased, but not significantly, at a dose of 1.25 mg/kg i.p. and decreased significantly at higher doses.
Negative_regulation (decreased) of growth hormone
14) Confidence 0.47 Published 1987 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 3449200 Disease Relevance 0 Pain Relevance 0.26
Patients vary in age from newborn infant to teenager, nevertheless slipped capital femoral epiphysis is probably the most common hip disease during adolescence, and is often associated with endocrine imbalance including growth hormone deficiency.
Negative_regulation (deficiency) of growth hormone in epiphysis associated with growth hormone deficiency and disease
15) Confidence 0.47 Published 1994 Journal Minerva Pediatr. Section Abstract Doc Link 8035756 Disease Relevance 0.43 Pain Relevance 0.07
Precocious puberty associated with growth hormone deficiency in a patient with craniopharyngioma: report of one case.
Negative_regulation (deficiency) of growth hormone associated with craniopharyngioma, precocious puberty and growth hormone deficiency
16) Confidence 0.43 Published 2001 Journal Acta Paediatr Taiwan Section Title Doc Link 11550415 Disease Relevance 1.20 Pain Relevance 0.08
Whether nicotine inhibits the electrical activity of the gonadotropin-releasing hormone (GnRH) pulse generator to suppress pulsatile LH secretion, and whether this suppression of LH secretion by nicotine is mediated by opioid neurons, were studied in ovariectomized rats by examining changes in LH secretion and the multiunit activity (MUA) of the medial basal hypothalamus.
Negative_regulation (inhibits) of gonadotropin-releasing hormone in neurons associated with nicotine and opioid
17) Confidence 0.42 Published 1999 Journal Psychoneuroendocrinology Section Abstract Doc Link 10341367 Disease Relevance 0 Pain Relevance 0.46
This inhibitory effect of nicotine on the GnRH pulse generator activity was not blocked by the prior injection of an opiate receptor antagonist naloxone (naloxone hydrochlolide, 2 mg/kg bw), which was effective in significantly decreasing the interval between MUA volleys.
Negative_regulation (blocked) of GnRH pulse generator associated with antagonist, nicotine, narcan and opiate
18) Confidence 0.42 Published 1999 Journal Psychoneuroendocrinology Section Abstract Doc Link 10341367 Disease Relevance 0 Pain Relevance 0.63
We suggest that growth hormone deficiency may be associated with maturation arrest, and the possibility of treatment with growth hormone should be considered.
Negative_regulation (deficiency) of growth hormone associated with growth hormone deficiency
19) Confidence 0.42 Published 1993 Journal Hum. Reprod. Section Abstract Doc Link 8345085 Disease Relevance 0.19 Pain Relevance 0.26
Intracranial hypertension is rare, but can occur in children with growth hormone deficiency, Ullrich-Turner syndrome or renal insufficiency during the first 8 to 12 weeks after the start of growth hormone treatment; it has seldom been reported in adults with growth hormone deficiency.
Negative_regulation (deficiency) of growth hormone associated with renal insufficiency, turner's syndrome, cva and growth hormone deficiency
20) Confidence 0.42 Published 1997 Journal Drug Saf Section Abstract Doc Link 9391774 Disease Relevance 1.06 Pain Relevance 0.21

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