INT136105

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.93
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleus (Pgr) enzyme binding (Pgr)
DNA binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
macrophages 1
Pgr (Mus musculus)
Pain Link Frequency Relevance Heat
Dismenorea 9 100.00 Very High Very High Very High
Pain 4 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
Analgesic 2 100.00 Very High Very High Very High
endometriosis 10 99.50 Very High Very High Very High
Neuropathic pain 3 99.44 Very High Very High Very High
allodynia 1 96.96 Very High Very High Very High
Hyperalgesia 1 96.40 Very High Very High Very High
intrathecal 1 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Endometriosis 11 99.50 Very High Very High Very High
Neuropathic Pain 4 99.44 Very High Very High Very High
Injury 1 98.72 Very High Very High Very High
Dysmenorrhea 6 98.20 Very High Very High Very High
Hyperalgesia 1 96.40 Very High Very High Very High
Disease 2 77.92 Quite High
INFLAMMATION 93 65.68 Quite High
Premature Birth 153 62.00 Quite High
Pain 1 59.24 Quite High
Reprotox - General 1 4 54.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Progesterone receptor antagonist is effective in relieving neuropathic pain.
Regulation (effective) of Progesterone receptor associated with analgesic, antagonist and neuropathic pain
1) Confidence 0.45 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16759651 Disease Relevance 0.47 Pain Relevance 1.45
Our finding suggests that progesterone resistance in endometriosis in general and the down regulation of PR-B, but not PR-A, in particular, are a result of promoter hypermethylation of PR-B, but not PR-A.
Regulation (regulation) of PR-B associated with endometriosis
2) Confidence 0.38 Published 2006 Journal Epigenetics : official journal of the DNA Methylation Society Section Abstract Doc Link 17965625 Disease Relevance 0.98 Pain Relevance 0.44
In rodents, direct treatment of DCs with progesterone has been shown to increase the inhibitory capacity of DCs and these changes are associated with progesterone receptor (PR) regulation.
Regulation (regulation) of progesterone receptor
3) Confidence 0.06 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 0.05 Pain Relevance 0.06
In rodents, direct treatment of DCs with progesterone has been shown to increase the inhibitory capacity of DCs and these changes are associated with progesterone receptor (PR) regulation.
Regulation (regulation) of PR
4) Confidence 0.06 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 0.05 Pain Relevance 0.06
Importantly, macrophages possess PR and are directly regulated by progesterone as their migration and nitric oxide production is severely impaired when progesterone levels are high.
Regulation (regulated) of PR in macrophages
5) Confidence 0.05 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 0.18 Pain Relevance 0.07
Immunoreactivity of progesterone receptor isoform B, nuclear factor kappaB, and IkappaBalpha in adenomyosis.
Regulation (Immunoreactivity) of progesterone receptor isoform B associated with dismenorea
6) Confidence 0.04 Published 2009 Journal Fertil. Steril. Section Title Doc Link 19296948 Disease Relevance 0.19 Pain Relevance 0.54

General Comments

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