INT136106

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 30
Total Number 34
Disease Relevance 8.43
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (DNMT3B) nucleus (DNMT3B) DNA binding (DNMT3B)
cytoplasm (DNMT3B)
Anatomy Link Frequency
body 2
muscle 1
DNMT3B (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 342 100.00 Very High Very High Very High
carpal tunnel syndrome 75 100.00 Very High Very High Very High
epidural 3 96.00 Very High Very High Very High
Arthritis 79 93.40 High High
Pain 117 91.36 High High
depression 3 87.08 High High
Spinal cord 4 84.28 Quite High
Analgesic 2 68.88 Quite High
Lasting pain 6 52.48 Quite High
Inflammation 3 52.40 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 352 100.00 Very High Very High Very High
Carpal Tunnel Syndrome 105 100.00 Very High Very High Very High
Targeted Disruption 2 99.66 Very High Very High Very High
Cognitive Disorder 40 99.14 Very High Very High Very High
Disease 147 98.76 Very High Very High Very High
Colon Cancer 1 97.48 Very High Very High Very High
Muscle Disease 10 96.32 Very High Very High Very High
Stomatitis 1 95.96 Very High Very High Very High
Chronic Fatigue Syndrome 22 94.84 High High
Rheumatoid Arthritis 61 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Each ICF was saved and three different analyses were conducted: one of the entire original text, one of only the paragraphs dealing with medical information and one of only the paragraphs dealing with statutory information.


Gene_expression (saved) of ICF
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2868027 Disease Relevance 0.08 Pain Relevance 0.09
The ICF highlights the complex relations between different components in disability and, as such, provides a useful framework to explain and understand the experiences of living with RA.
Gene_expression (highlights) of ICF associated with arthritis
2) Confidence 0.56 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2499996 Disease Relevance 0.23 Pain Relevance 0.15
Relevant aspects that could not be expressed in ICF categories
Gene_expression (categories) of ICF
3) Confidence 0.55 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2862019 Disease Relevance 0.22 Pain Relevance 0
Properties of the ICF items
Gene_expression (items) of ICF
4) Confidence 0.55 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1199614 Disease Relevance 0 Pain Relevance 0
Immeasurability of the ICF items
Gene_expression (items) of ICF
5) Confidence 0.55 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1199614 Disease Relevance 0 Pain Relevance 0
The mean rank of the importance rating changed over time (p < 0.0001) for all four ICF components (Body Function: ?
Gene_expression (components) of ICF in Body
6) Confidence 0.53 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2614963 Disease Relevance 0 Pain Relevance 0
Subsequent experiments on healthy subjects showed that a conditioning stimulus capable of producing ICF of MEPs had no effect on the EMG response evoked by transmastoidal electrical stimulation of corticospinal tract.
Gene_expression (producing) of ICF
7) Confidence 0.53 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16760345 Disease Relevance 0.08 Pain Relevance 0.24
A Comprehensive ICF Core Set was selected for the comprehensive classification of functioning and a Brief ICF Core Set for application in trials.
Gene_expression (selected) of ICF
8) Confidence 0.51 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 19282309 Disease Relevance 0.14 Pain Relevance 0
OPCML-v1 could also be induced in the colorectal cancer cell line HCT116 which is completely methylated for this gene, by genetic demethylation through double knock-out of both DNA methyltransferases DNMT1 and DNMT3B (DKO cell line) [25] (Fig. 4B).
Gene_expression (methyltransferases) of DNMT3B associated with targeted disruption and colon cancer
9) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.64 Pain Relevance 0
Sixteen ICF categories of the ICF Core Sets (13%) could not be linked with LEP nursing interventions (see Table 3).
Gene_expression (categories) of ICF
10) Confidence 0.37 Published 2008 Journal BMC Nurs Section Body Doc Link PMC2276191 Disease Relevance 0 Pain Relevance 0.04
The ICF was used in this study to guide the conceptualization and structure of the PIPP with the inclusion of subscales representing many of the ICF elements that have been proposed as core domains for a wide spectrum of serious health conditions.
Gene_expression (used) of ICF
11) Confidence 0.36 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1526715 Disease Relevance 0.17 Pain Relevance 0.04
The frequency with which the domains and categories of the ICF were assessed in all 28 studies is presented in Figure 2.
Gene_expression (assessed) of ICF
12) Confidence 0.33 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1713237 Disease Relevance 0.40 Pain Relevance 0.33
Linking outcomes assessed in CTS trials with the ICF
Gene_expression (assessed) of ICF associated with carpal tunnel syndrome
13) Confidence 0.33 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1713237 Disease Relevance 0.47 Pain Relevance 0.39
Further work is needed to review the psychometric properties of existing instruments in CTS populations and to develop consensus on a core set of outcome measures to be used in future clinical trials for CTS which crosses all three domains of the ICF.


Gene_expression (crosses) of ICF associated with carpal tunnel syndrome
14) Confidence 0.33 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1713237 Disease Relevance 0.26 Pain Relevance 0.26
ODI is scored on a six point Likert scale whereas WHODAS II and the Comprehensive ICF Core Set for LBP are scored on five point scales.
Gene_expression (scored) of ICF associated with backache
15) Confidence 0.32 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.15 Pain Relevance 0.15
These problems may be linked to ICF categories b144 Memory functions and b164 Higher-level cognitive functions, which were not included in the present ICF Core Set.
Neg (not) Gene_expression (present) of ICF associated with cognitive disorder
16) Confidence 0.32 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.52 Pain Relevance 0.42
This problem applies partly to the ICF classification and partly to the reduction of ICF categories in the present Comprehensive ICF Core Set.
Gene_expression (present) of ICF
17) Confidence 0.32 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.39 Pain Relevance 0.39
It is worth to realize this shortcoming when applying the Comprehensive ICF Core Set for LBP in practice.
Gene_expression (applying) of ICF associated with backache
18) Confidence 0.32 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.68 Pain Relevance 0.50
Sixteen ICF categories of the ICF Core Sets (13%) could not be linked with LEP nursing interventions (see Table 3).
Gene_expression (categories) of ICF
19) Confidence 0.32 Published 2008 Journal BMC Nurs Section Body Doc Link PMC2276191 Disease Relevance 0 Pain Relevance 0.04
Linked ICF categories covered by the Comprehensive ICF Core Set for LBP
Gene_expression (categories) of ICF associated with backache
20) Confidence 0.28 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.56 Pain Relevance 0.56

General Comments

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