INT136121

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.15
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (MGAT1) Golgi apparatus (MGAT1) carbohydrate metabolic process (MGAT1)
MGAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 1 91.36 High High
orphanin 4 88.64 High High
Opioid 1 75.00 Quite High
Endocannabinoid 8 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Cannabinoid receptor 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 17 96.74 Very High Very High Very High
Disease 7 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 6 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Metastasis 3 5.00 Very Low Very Low Very Low
Influenza Virus Infection 3 5.00 Very Low Very Low Very Low
Wrinkles 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A novel class of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-ones have been discovered and developed as potent and selective GlyT1 inhibitors.
Negative_regulation (inhibitors) of GlyT1
1) Confidence 0.19 Published 2006 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 16762548 Disease Relevance 0 Pain Relevance 0.28
A genetically engineered E. coli strain has been developed by Den et al. [91] in which GlcN-6-P acetyltransferase, GlcN-6-P synthase and GlcN-1-P acetyltransferase are overexpressed, while GlcN-6-P and GlcNAc-1-P uridyltransferase are suppressed.
Negative_regulation (suppressed) of GlcNAc-1-P associated with sprains and strains
2) Confidence 0.05 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 0.10 Pain Relevance 0
Indeed, MGAT activity was decreased by 60% in Dga1p-deficient preparations, compared to the wild-type control (1.93 ± 0.30 and 0.77 ± 0.13 nmol/h?
Negative_regulation (decreased) of MGAT
3) Confidence 0.03 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0.05 Pain Relevance 0

General Comments

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